Discovery of a New Human Polyomavirus Associated with Trichodysplasia Spinulosa in an Immunocompromized Patient
Figure 5
Amino acid sequence of the TSV large T protein.
Indicated are three major domains found in the large T amino acid sequence; the J-domain (blue-shaded box), the ori DNA-binding domain (yellow-shaded box) and the helicase domain (green-shaded box). Within the J-domain the putative locations of conserved region 1 and the HPDKGG motif are depicted. Downstream of the J-domain, a pRb family-binding motif and nuclear localization signal are located. In the helicase domain, a zinc finger motif, NTPase-binding ‘Walker’ motifs A and B and an helicase SF3 (superfamily 3) motif C are located.