A Systems Immunology Approach to Plasmacytoid Dendritic Cell Function in Cytopathic Virus Infections
Figure 5
Effect of type I IFN secretion rate on protection against disease.
(A) Kinetics of MHV in spleen (upper row) and liver (middle row), and impact on disease severity (bottom row) for normal (solid line), 10-fold reduced (broken line) or 100-fold (dotted line) reduced IFN secretion rate by pDCs after low (5×101 pfu), intermediate (5×103 pfu) and high (5×105 pfu) dose infection. (B) Dependence of peak virus titers in spleen (B) and liver (C) after infection with the indicated doses on the relative reduction rate of IFN secretion rate by pDCs at 48 h post infection (i.v. infection with indicated doses). (D) Disease severity determined as ALT levels in serum at 48 h post infection (i.v. infection with indicated doses) depending on the relative reduction rate of IFN secretion rate by pDCs.