Homeostatic Interplay between Bacterial Cell-Cell Signaling and Iron in Virulence
Figure 5
Homeostatic interplay between PQS and iron: Iron fine-tunes PQS activities.
The effect of iron on MvfR induction was tested using the pqsA-GFP reporter in PA14 (A) and PA14 pqsA−::pqsH cells treated with PQS (1 mg/L) (B). The effect of iron on pyocyanin production was tested when PQS was supplied at 1 mg/L or 20 mg/L (C). The cells were grown in low iron medium D-TSB or in media supplemented with iron (FeCl3 or FeSO4, 200 µM). Asterisks show samples that are statistically significant different (P value<0.05) from the PQS 1 mg/L treated sample.