Efficacy of the New Neuraminidase Inhibitor CS-8958 against H5N1 Influenza Viruses
Figure 2
Therapeutic efficacy of CS-8958 and oseltamivir phosphate against oseltamivir-resistant H5N1 influenza viruses in mice.
Eight mice per group were intranasally infected with 4 MLD50 of wild-type VN1203 (A), VN1203-H274Y (B), or VN1203-N294S (C). The infected mice were given CS-8958 intranasally or oseltamivir phosphate orally at the indicated doses 2 h post-infection (pi) or twice daily for 5 days beginning 2 h pi. Control mice received saline and water 2 h pi. Survival was monitored daily for 21 days. P values were calculated by a log-rank test using a joint ranking method. Asterisk, P<0.05.