Transmission of Influenza Virus in a Mammalian Host Is Increased by PB2 Amino Acids 627K or 627E/701N
Figure 5
Contact transmission of rVN1203 wild-type, rVN1203 627E and rVN1203 627E 701N viruses in guinea pigs.
Nasal wash titers are plotted as a function of time post-inoculation. Titers of intranasally inoculated animals are represented by dashed lines and filled squares; titers of exposed guinea pigs are shown with solid lines and filled triangles. (A) Transmission of rVN1203 wild-type virus. (B) Transmission of the rVN1203 627E mutant. (C) Transmission of the rVN1203 627E 701N double mutant.