Pseudomonas aeruginosa Suppresses Host Immunity by Activating the DAF-2 Insulin-Like Signaling Pathway in Caenorhabditis elegans
Figure 6
Intestinal DAF-16 is specifically required for resistance to P. aeruginosa.
(A–B) Survival of worms cultured on PA14 lawns was monitored over time at 25°C. (A) In wildtype N2 worms, the effects on survival of RNAi knockdown of daf-16 or control RNAi were indistinguishable (logrank, p = 0.85). (B) In VP303 worms, intestinally restricted RNAi knockdown of daf-16 caused enhanced sensitivity to PA14 compared to control RNAi (logrank, p = 0.0002).