A New Perspective on Listeria monocytogenes Evolution
Figure 4
A) Distribution of the polymorphisms along the 2,400 nt of gene inlA in the 33 distinct inlA alleles encountered. The scale above the graph is in amino-acids (AA). InlA functional domains are represented as distinct blocks: signal peptide (SP), alpha-domain linker, leucine-rich repeats (LRR), Ig-like, B-repeat, Pre-anchor (PA) and cell wall anchor (CWA). Vertical bars above these blocks, correspond to synonymous nucleotide polymorphisms; below these blocks, non-synonymous polymorphisms resulting in amino-acid changes. Note that the LRR domain, especially repeats 7 to 15, is highly conserved. Triangles indicate the position of premature stop codons (PMSC) observed in this study and previous reports; black triangles: PMSCs observed in clonal complex CC9; red: PMSCs in other clones; see Table 4 for details. B) Deduced amino-acid polymorphisms in InlA. Lineages in which the inlA alleles were found are indicated on the left (1, 2 or 3). Blocks of amino-acids that are identical to the sequence in reference strain EGDe (allele 8) are color-shaded. Note the mosaic pattern, with blocks of polymorphisms shared between distinct groups of alleles when scrolling along the sequence.