Anti-Fungal Innate Immunity in C. elegans Is Enhanced by Evolutionary Diversification of Antimicrobial Peptides
Figure 5
Overexpression of the nlp-29 locus.
A Transgenic worms carrying extra copies of the nlp-29 locus have elevated levels of gene expression. The level of gene expression for the 6 genes of the nlp-29 locus was compared between transgenic worms carrying a DNA fragment specifically encompassing the locus (+) and non-transgenic worms (−), either following D. coniospora infection (yellow) or not (blue). B Overexpression of the nlp-29 locus is associated with increased resistance to infection. Transgenic worms carrying the nlp-29 locus (in light blue) are more resistant to D. coniospora infection than their non-transgenic sibling (in red). The difference in survival is highly significant (p<0.001, one-side log rank test).