Specific Remodeling of Splenic Architecture by Cytomegalovirus
Figure 5
MCMV-Induced Suppression of CCL21 Abolishes T Cell Localization to the White Pulp
Mock- or MCMV-infected B6 mice (1.5 × 105 pfu) were injected with CFSE labeled naive T cells, and spleens were removed for analysis 2 h later.
(A) Flow cytometry was used to assess the total number of CFSE-labeled cells in the spleen after adoptive transfer into mice 3 d post-infection.
(B) Immunohistochemical analysis of T cell localization in the spleen at 3 d post-infection using the MOMA-1 marker to identify MMM (shown in blue, magnification 10×). WP, white pulp; RP, red pulp.