Exercise promotes host anti-infection activity through CNDP2 metabolite-mediated inflammasome hyperactivation

• Yan Qian ,

  Contributed equally to this work with: Yan Qian, Xiangyun Cheng

  Roles Formal analysis, Investigation, Visualization, Writing – review & editing

  Affiliations Beijing Life Science Academy, Beijing, China, Department of Immunology, School of Basic Medical Sciences, State Key Laboratory of Molecular Oncology, Peking University, Beijing, China, Key Laboratory of Molecular Immunology, Chinese Academy of Medical Sciences, Beijing, China, Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing, China

  ⨯
• Xiangyun Cheng ,

  Contributed equally to this work with: Yan Qian, Xiangyun Cheng

  Roles Investigation, Methodology, Resources

  Affiliations Department of Sports Medicine, Peking University Third Hospital, Beijing, China, Beijing Key Laboratory of Sports Injuries, Institute of Sports Medicine of Peking University, Beijing, China

  ⨯
• Qiannv Liu,

  Roles Investigation, Validation

  Affiliations Department of Immunology, School of Basic Medical Sciences, State Key Laboratory of Molecular Oncology, Peking University, Beijing, China, Key Laboratory of Molecular Immunology, Chinese Academy of Medical Sciences, Beijing, China, Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing, China

  ⨯
• Chunlei Wang,

  Roles Investigation, Validation

  Affiliations Department of Immunology, School of Basic Medical Sciences, State Key Laboratory of Molecular Oncology, Peking University, Beijing, China, Key Laboratory of Molecular Immunology, Chinese Academy of Medical Sciences, Beijing, China, Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing, China

  ⨯
• Chun Kong,

  Roles Investigation, Validation

  Affiliations Department of Immunology, School of Basic Medical Sciences, State Key Laboratory of Molecular Oncology, Peking University, Beijing, China, Key Laboratory of Molecular Immunology, Chinese Academy of Medical Sciences, Beijing, China, Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing, China

  ⨯
• Mengqian Li,

  Roles Investigation, Validation

  Affiliations Department of Immunology, School of Basic Medical Sciences, State Key Laboratory of Molecular Oncology, Peking University, Beijing, China, Key Laboratory of Molecular Immunology, Chinese Academy of Medical Sciences, Beijing, China, Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing, China

  ⨯
• Xiangyang Geng,

  Roles Investigation, Validation

  Affiliations Department of Immunology, School of Basic Medical Sciences, State Key Laboratory of Molecular Oncology, Peking University, Beijing, China, Key Laboratory of Molecular Immunology, Chinese Academy of Medical Sciences, Beijing, China, Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing, China

  ⨯
• Liya Ai,

  Roles Resources, Validation

  Affiliations Department of Sports Medicine, Peking University Third Hospital, Beijing, China, Beijing Key Laboratory of Sports Injuries, Institute of Sports Medicine of Peking University, Beijing, China

  ⨯
• Mindi Zhao,

  Roles Data curation, Resources

  Affiliation Department of Laboratory Medicine, Beijing Hospital, National Center for Gerontology, National Clinical Research Center for Gerontology, The Key Laboratory of Geriatrics of NHC, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China

  ⨯
• Shuo Wang,

  Roles Funding acquisition, Project administration

  Affiliation CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

  ⨯
• Dong Jiang ,

  Roles Project administration, Resources, Writing – original draft

  * E-mail: xiap@pku.edu.cn (PX); bysyjiangdong@126.com (DJ)

  Affiliations Department of Sports Medicine, Peking University Third Hospital, Beijing, China, Beijing Key Laboratory of Sports Injuries, Institute of Sports Medicine of Peking University, Beijing, China

  ⨯
• Pengyan Xia

  Roles Conceptualization, Formal analysis, Funding acquisition, Visualization, Writing – original draft

  * E-mail: xiap@pku.edu.cn (PX); bysyjiangdong@126.com (DJ)

  Affiliations Department of Immunology, School of Basic Medical Sciences, State Key Laboratory of Molecular Oncology, Peking University, Beijing, China, Key Laboratory of Molecular Immunology, Chinese Academy of Medical Sciences, Beijing, China, Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing, China

  https://orcid.org/0000-0001-7959-5796

  ⨯