The two-component system ColRS discriminates metal signals to regulate virulence and resistance in Pseudomonas aeruginosa

Ninglin Zhao; Ziqi Zhu; Xiyu Wu; Jianping Ying; Dan Fan; Cheng Nong; Yingjie Song; Tonggen Liu; Chenxi Duan; Yaping Zheng; Shuang Zou; Xingyu Mou; Rui Bao

doi:10.1371/journal.ppat.1014538

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Open Access

Peer-reviewed

Research Article

The two-component system ColRS discriminates metal signals to regulate virulence and resistance in Pseudomonas aeruginosa

Ninglin Zhao ,

Contributed equally to this work with: Ninglin Zhao, Ziqi Zhu, Xiyu Wu

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

Affiliation Division of Infectious Diseases in State Key Laboratory of Biotherapy, Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China
⨯
Ziqi Zhu ,

Contributed equally to this work with: Ninglin Zhao, Ziqi Zhu, Xiyu Wu

Roles Data curation, Formal analysis, Supervision, Writing – original draft, Writing – review & editing

Affiliation Division of Infectious Diseases in State Key Laboratory of Biotherapy, Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China
⨯
Xiyu Wu ,

Contributed equally to this work with: Ninglin Zhao, Ziqi Zhu, Xiyu Wu

Roles Data curation, Formal analysis

Affiliation Advanced Mass Spectrometry Center, Research Core Facility, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China
⨯
Jianping Ying,

Roles Investigation, Validation

Affiliation Division of Infectious Diseases in State Key Laboratory of Biotherapy, Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China
⨯
Dan Fan,

Roles Investigation, Validation

Affiliation Division of Infectious Diseases in State Key Laboratory of Biotherapy, Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China
⨯
Cheng Nong,

Roles Investigation

Affiliation Division of Infectious Diseases in State Key Laboratory of Biotherapy, Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China
⨯
Yingjie Song,

Roles Investigation

Affiliation College of Life Science, Sichuan Normal University, Chengdu, China
⨯
Tonggen Liu,

Roles Investigation

Affiliation Division of Infectious Diseases in State Key Laboratory of Biotherapy, Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China
⨯
Chenxi Duan,

Roles Methodology

Affiliation Division of Infectious Diseases in State Key Laboratory of Biotherapy, Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China
⨯
Yaping Zheng,

Roles Methodology

Affiliation Division of Infectious Diseases in State Key Laboratory of Biotherapy, Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China
⨯
Shuang Zou,

Roles Methodology

Affiliation Division of Infectious Diseases in State Key Laboratory of Biotherapy, Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China
⨯
Xingyu Mou,

Roles Methodology

Affiliation Division of Infectious Diseases in State Key Laboratory of Biotherapy, Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China
⨯
Rui Bao

Roles Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: baorui@scu.edu.cn

Affiliation Division of Infectious Diseases in State Key Laboratory of Biotherapy, Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China

https://orcid.org/0000-0002-6083-8716

⨯

The two-component system ColRS discriminates metal signals to regulate virulence and resistance in Pseudomonas aeruginosa

Ninglin Zhao,
Ziqi Zhu,
Xiyu Wu,
Jianping Ying,
Dan Fan,
Cheng Nong,
Yingjie Song,
Tonggen Liu,
Chenxi Duan,
Yaping Zheng

Published: August 28, 2026
https://doi.org/10.1371/journal.ppat.1014538

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