Rationally designed minimized TbpB confers broad protection against meningococcal infection

• Epshita A. Islam ,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Writing – original draft

  ¶☯ Authors contributed equally.

  Affiliation Department of Biochemistry, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada

  ⨯
• Jamie E. Fegan ,

  Roles Conceptualization, Formal analysis, Investigation, Writing – original draft

  ¶☯ Authors contributed equally.

  Affiliation Department of Molecular Genetics, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada

  ⨯
• Gregory B. Cole,

  Roles Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliation Department of Biochemistry, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada

  ⨯
• Charles Calmettes,

  Roles Investigation, Writing – review & editing, Formal analysis

  Present address: INRS – Centre Armand-Frappier Santé Biotechnologie, Laval, Canada.

  Affiliation Department of Biochemistry, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada

  ⨯
• Dixon Ng,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Biochemistry, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada

  ⨯
• Natalie Y. T. Au,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Department of Biochemistry, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada

  ⨯
• Carolyn Marion,

  Roles Investigation, Writing – review & editing

  Present address National Institutes of Health, Bethesda, USA.

  Affiliation Department of Molecular Genetics, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada

  ⨯
• Sang K. Ahn,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Molecular Genetics, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada

  ⨯
• David M. Curran,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of Biochemistry, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada

  ⨯
• Laura-lee Caruso,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Molecular Genetics, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada

  ⨯
• Anthony B. Schryvers,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  Affiliation Department of Microbiology, Immunology, and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, Canada

  ⨯
• Trevor F. Moraes ,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  * E-mail: trevor.moraes@utoronto.ca (TFM), scott.gray.owen@utoronto.ca (SDG-O)

  Affiliation Department of Biochemistry, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada

  ⨯
• Scott D. Gray-Owen

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  * E-mail: trevor.moraes@utoronto.ca (TFM), scott.gray.owen@utoronto.ca (SDG-O)

  Affiliation Department of Molecular Genetics, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada

  https://orcid.org/0000-0002-1477-3616

  ⨯