The C5a-C5aR1 axis facilitates blood-brain barrier disruption induced by EV-A71 infection through neutrophil activation

• Peiyu Zhu ,

  Contributed equally to this work with: Peiyu Zhu, Xiaofeng Zeng

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, China, Henan International Joint Laboratory of Children's Infectious Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, China

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• Xiaofeng Zeng ,

  Contributed equally to this work with: Peiyu Zhu, Xiaofeng Zeng

  Roles Resources, Validation

  Affiliation Department of Forensic Medicine, School of Forensic Medicine, Kunming Medical University, Kunming, China

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• Xin Yuan,

  Roles Investigation, Methodology

  Affiliation Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, China

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• Zijie Li,

  Roles Project administration

  Affiliation Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, China

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• Wangquan Ji,

  Roles Investigation, Methodology, Project administration, Supervision

  Affiliation Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, China

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• Dong Li,

  Roles Investigation, Methodology, Validation

  Affiliation Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, China

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• Tiantian Sun,

  Roles Visualization

  Affiliation Department of Infection Control, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China

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• Haiyan Yang,

  Roles Supervision

  Affiliation Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, China

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• Shuaiyin Chen,

  Roles Funding acquisition, Supervision

  Affiliation Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, China

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• Jinzhao Long,

  Roles Supervision

  Affiliation Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, China

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• Fang Wang,

  Roles Resources

  Affiliation Henan International Joint Laboratory of Children's Infectious Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, China

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• Yaodong Zhang,

  Roles Resources

  Affiliation Henan International Joint Laboratory of Children's Infectious Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, China

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• Adong Shen,

  Roles Resources

  Affiliations Henan International Joint Laboratory of Children's Infectious Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, China, Key Laboratory of Major Diseases in Children, Ministry of Education, National Center for Children's Health, Beijing Children's Hospital, Beijing, China

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• Weiguo Zhang,

  Roles Funding acquisition, Supervision, Writing – review & editing

  Affiliation National Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China

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• Yuefei Jin ,

  Roles Conceptualization, Funding acquisition, Writing – original draft, Writing – review & editing

  * E-mail: jyf201907@zzu.edu.cn

  Affiliations Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, China, Henan International Joint Laboratory of Children's Infectious Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, China, Pingyuan Laboratory, Xinxiang, China

  https://orcid.org/0000-0002-5084-5859

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•  [ ... ],
• Guangcai Duan

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  Affiliation Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, China

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