Topical formulation of repurposed FDA-approved compounds inhibits Pseudomonas aeruginosa ExoU and improves corneal infection outcomes

• Daniel M. Foulkes ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: daniel.foulkes@liv.ac.uk

  Affiliations Department of Eye and Vision Sciences, Institute of Life Course and Medical Sciences (ILCAMS), University of Liverpool, Liverpool, United Kingdom, Department of Biochemistry, Cell and Systems biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, United Kingdom

  https://orcid.org/0000-0002-1021-6740

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• David G. Fernig,

  Roles Conceptualization, Funding acquisition, Investigation, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Biochemistry, Cell and Systems biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, United Kingdom

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• Keri McLean,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Eye and Vision Sciences, Institute of Life Course and Medical Sciences (ILCAMS), University of Liverpool, Liverpool, United Kingdom

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• Marie Held,

  Roles Data curation, Formal analysis, Methodology, Resources, Software, Writing – review & editing

  Affiliation Centre for Cell Imaging, Technology, Infrastructure and Environment Directorate, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, United Kingdom

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• John A. Harris,

  Roles Investigation

  Affiliation Department of Biochemistry, Cell and Systems biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, United Kingdom

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• Yan Sun,

  Roles Investigation, Methodology

  Affiliations Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States of America, Department of Ophthalmic Research, Cleveland Clinic Research, Cleveland, Ohio, United States of America

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• Joanne L. Fothergill,

  Roles Conceptualization, Resources, Supervision

  Affiliation Department of Clinical Infection, Microbiology and Immunology, Institute of Infection, Veterinary & Ecological Sciences, University of Liverpool, Liverpool, United Kingdom

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• Valerie Price,

  Roles Investigation, Validation, Writing – review & editing

  Affiliation Department of Biochemistry, Cell and Systems biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, United Kingdom

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• Dominic P. Byrne,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Biochemistry, Cell and Systems biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, United Kingdom

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• Gabriela Czanner,

  Roles Formal analysis, Methodology

  Affiliation Faculty of Engineering and Physical Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom

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• Connie Tam,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Visualization, Writing – review & editing

  Affiliations Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States of America, Department of Ophthalmic Research, Cleveland Clinic Research, Cleveland, Ohio, United States of America, Department of Ophthalmology, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America

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• Stephen B. Kaye

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Supervision, Visualization, Writing – review & editing

  Affiliation Department of Eye and Vision Sciences, Institute of Life Course and Medical Sciences (ILCAMS), University of Liverpool, Liverpool, United Kingdom

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