ddOTs: A multiplexed quantitative ddPCR approach for resolving overlapping hepatitis B virus transcripts to decipher cccDNA-driven transcription

• Nazim Sarica ,

  Contributed equally to this work with: Nazim Sarica, Oceane Lopez

  Roles Conceptualization, Investigation, Methodology, Visualization, Writing – original draft

  Affiliation Institut de Génétique Humaine. Laboratoire de Virologie Moléculaire, Université de Montpellier, CNRS, Montpellier, France

  ⨯
• Oceane Lopez ,

  Contributed equally to this work with: Nazim Sarica, Oceane Lopez

  Roles Investigation, Visualization

  Affiliation Institut de Génétique Humaine. Laboratoire de Virologie Moléculaire, Université de Montpellier, CNRS, Montpellier, France

  https://orcid.org/0009-0009-4921-4580

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• João Diogo Dias,

  Roles Investigation, Writing – review & editing

  Affiliation Institut de Génétique Humaine. Laboratoire de Virologie Moléculaire, Université de Montpellier, CNRS, Montpellier, France

  ⨯
• Victor Boschetti,

  Roles Investigation, Visualization

  Affiliation Centre International de Recherche en Infectiologie (CIRI), INSERM, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, France

  https://orcid.org/0009-0007-3536-660X

  ⨯
• Irene Meki,

  Roles Investigation, Methodology

  Current address: Animal Production and Health Laboratory, Joint FAO/IAEA Centre of Nuclear Techniques in Food and Agriculture, Department of Nuclear Sciences and Applications, International Atomic Energy Agency, Wagramer strasse 5, A1400, Vienna, Austria

  Affiliation Institut de Génétique Humaine. Laboratoire de Virologie Moléculaire, Université de Montpellier, CNRS, Montpellier, France

  ⨯
• Basile Jay,

  Roles Methodology

  Affiliation Institut de Génétique Humaine. Laboratoire de Virologie Moléculaire, Université de Montpellier, CNRS, Montpellier, France

  https://orcid.org/0000-0001-8573-8722

  ⨯
• Gael Petitjean,

  Roles Methodology

  Affiliation Institut de Génétique Humaine. Laboratoire de Virologie Moléculaire, Université de Montpellier, CNRS, Montpellier, France

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• David Durantel,

  Roles Conceptualization, Validation, Writing – review & editing

  Affiliation Centre International de Recherche en Infectiologie (CIRI), INSERM, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, France

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• Christine Neuveut

  Roles Conceptualization, Funding acquisition, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: christine.neuveut@igh.cnrs.fr

  Affiliation Institut de Génétique Humaine. Laboratoire de Virologie Moléculaire, Université de Montpellier, CNRS, INSERM, Montpellier, France

  https://orcid.org/0000-0001-6520-271X

  ⨯