TREM2 plays a critical role in innate immune defense against acute Toxoplasma gondii infection by promoting macrophage antimicrobial activities

• Hannah Z. Debray,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California, United States of America, Institute for Immunology, University of California, Irvine, California, United States of America

  ⨯
• Dillon Cheng,

  Roles Investigation, Methodology

  Affiliations Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California, United States of America, Institute for Immunology, University of California, Irvine, California, United States of America

  ⨯
• L. Angel Ayala,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California, United States of America, Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, California, United States of America

  https://orcid.org/0000-0002-6272-3314

  ⨯
• Toan Lam,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California, United States of America

  ⨯
• Ji-Hun Shin,

  Roles Formal analysis, Investigation, Methodology

  Affiliations Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California, United States of America, Institute for Immunology, University of California, Irvine, California, United States of America

  ⨯
• Dequina A. Nicholas,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliations Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California, United States of America, Institute for Immunology, University of California, Irvine, California, United States of America

  ⨯
• Matthew A. Inlay,

  Roles Conceptualization, Formal analysis, Methodology

  Affiliations Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California, United States of America, Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, California, United States of America

  ⨯
• Nir Drayman,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliations Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California, United States of America, Institute for Immunology, University of California, Irvine, California, United States of America

  ⨯
• Robert A. Edwards,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Department of Pathology, University of California, Irvine, School of Medicine, Irvine, California, United States of America

  ⨯
• Melissa B. Lodoen

  Roles Conceptualization, Formal analysis, Funding acquisition, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: mlodoen@uci.edu

  Affiliations Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California, United States of America, Institute for Immunology, University of California, Irvine, California, United States of America

  https://orcid.org/0000-0002-3366-6840

  ⨯