DNA oligonucleotides block viral entry of SARS-CoV-2 Omicron variants

• Jorge A. Acuña ,

  Contributed equally to this work with: Jorge A. Acuña, Benjamin Gabriel, Kasirajan Ayyanathan

  Roles Formal analysis, Funding acquisition, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Benjamin Gabriel ,

  Contributed equally to this work with: Jorge A. Acuña, Benjamin Gabriel, Kasirajan Ayyanathan

  Roles Formal analysis, Investigation, Visualization, Writing – original draft

  Affiliation Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Kasirajan Ayyanathan ,

  Contributed equally to this work with: Jorge A. Acuña, Benjamin Gabriel, Kasirajan Ayyanathan

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Jesse Miller,

  Roles Investigation, Resources

  Affiliation Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Yue Li,

  Roles Investigation

  Affiliation Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Kanupriya Whig,

  Roles Investigation, Visualization

  Affiliation Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Yongqing Zhu,

  Roles Investigation, Visualization

  Affiliation Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Marisa McGrath,

  Roles Resources

  Affiliation Center for Pathogen Research, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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• Peter Hewins,

  Roles Investigation, Methodology

  Affiliation Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Kellie Ann Jurado,

  Roles Conceptualization, Investigation, Resources, Supervision

  Affiliation Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Matthew B. Frieman,

  Roles Resources, Writing – review & editing

  Affiliation Center for Pathogen Research, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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• David C. Schultz,

  Roles Formal analysis, Investigation, Resources, Supervision, Writing – review & editing

  Affiliation Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Sara Cherry

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: Cherrys@pennmedicine.upenn.edu

  Affiliations Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  https://orcid.org/0000-0003-3956-6610

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