Fibrillarin-mediated 2’-O-methylation serves as a translation brake on uncapped enterovirus RNA

Kui Zhang; Xuliu Zhou; Baocheng Yu; Xiang Guo; Li Zuo; Lishi Liu; Zhen Chen; Xueyan Zhang; Haojie Hao; Huanzhou Xu; Fang Huang; Wuxiang Guan; Haibin Liu

doi:10.1371/journal.ppat.1014455

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Open Access

Peer-reviewed

Research Article

Fibrillarin-mediated 2’-O-methylation serves as a translation brake on uncapped enterovirus RNA

Kui Zhang,

Roles Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – review & editing

Affiliations Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China, State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China, University of Chinese Academy of Sciences, Beijing, China
⨯
Xuliu Zhou,

Roles Investigation, Validation, Writing – review & editing

Affiliations Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China, State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, Hubei, China
⨯
Baocheng Yu,

Roles Investigation, Validation, Writing – review & editing

Affiliations Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China, State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China, University of Chinese Academy of Sciences, Beijing, China
⨯
Xiang Guo,

Roles Validation, Writing – review & editing

Affiliations Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China, State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China, University of Chinese Academy of Sciences, Beijing, China
⨯
Li Zuo,

Roles Validation, Writing – review & editing

Affiliations Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China, State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China, University of Chinese Academy of Sciences, Beijing, China
⨯
Lishi Liu,

Roles Validation, Writing – review & editing

Affiliations Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China, State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China, Hubei Jiangxia Laboratory, Wuhan, Hubei, China
⨯
Zhen Chen,

Roles Writing – review & editing

Affiliations Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China, State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China
⨯
Xueyan Zhang,

Roles Validation, Writing – review & editing

Affiliations Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China, State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China
⨯
Haojie Hao,

Roles Validation, Writing – review & editing

Affiliations Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China, State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China
⨯
Huanzhou Xu,

Roles Supervision, Writing – review & editing

Affiliations Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China, State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China
⨯
Fang Huang,

Roles Supervision, Writing – review & editing

Affiliation Hubei Jiangxia Laboratory, Wuhan, Hubei, China
⨯
Wuxiang Guan ,

Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing

* E-mail: hbliu@wh.iov.cn (HL); guanwx@wh.iov.cn (WG)

Affiliations Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China, State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China
⨯
Haibin Liu

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: hbliu@wh.iov.cn (HL); guanwx@wh.iov.cn (WG)

Affiliations Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China, State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China, Hubei Jiangxia Laboratory, Wuhan, Hubei, China

https://orcid.org/0000-0003-3601-6066

⨯

Fibrillarin-mediated 2’-O-methylation serves as a translation brake on uncapped enterovirus RNA

Kui Zhang,
Xuliu Zhou,
Baocheng Yu,
Xiang Guo,
Li Zuo,
Lishi Liu,
Zhen Chen,
Xueyan Zhang,
Haojie Hao,
Huanzhou Xu

Published: July 20, 2026
https://doi.org/10.1371/journal.ppat.1014455

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