The residue 86 of the Getah virus E2 glycoprotein mediates both glycosaminoglycan- and LDLR-dependent infection

Xiangshu Qiu; Rongguang Lu; Jiaxin Tian; He Zhang; Jiyong Zhou; Mengsi Sun; Xinyu Cao; Xiangyu Zhu; Bocheng Liu; Qihui Yu; Yuanyuan Li; Hualei Wang; Ningyi Jin; Huijun Lu; Ning Shi

doi:10.1371/journal.ppat.1014453

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Open Access

Peer-reviewed

Research Article

The residue 86 of the Getah virus E2 glycoprotein mediates both glycosaminoglycan- and LDLR-dependent infection

Xiangshu Qiu ,

Contributed equally to this work with: Xiangshu Qiu, Rongguang Lu

Roles Investigation, Methodology, Project administration, Writing – original draft

Affiliations MOA Key Laboratory of Animal Virology, Zhejiang University Center for Veterinary Sciences, Hangzhou, China, State Key Laboratory of Pathogen and Biosecurity, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China
⨯
Rongguang Lu ,

Contributed equally to this work with: Xiangshu Qiu, Rongguang Lu

Roles Conceptualization, Methodology, Writing – review & editing

Affiliation Institute of Infectious Diseases, Shenzhen Bay Laboratory, Shenzhen, China
⨯
Jiaxin Tian,

Roles Investigation, Project administration, Validation

Affiliations MOA Key Laboratory of Animal Virology, Zhejiang University Center for Veterinary Sciences, Hangzhou, China, State Key Laboratory of Pathogen and Biosecurity, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China
⨯
He Zhang,

Roles Data curation, Investigation, Visualization

Affiliation State Key Laboratory of Pathogen and Biosecurity, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China
⨯
Jiyong Zhou,

Roles Data curation, Formal analysis, Writing – review & editing

Affiliation MOA Key Laboratory of Animal Virology, Zhejiang University Center for Veterinary Sciences, Hangzhou, China
⨯
Mengsi Sun,

Roles Methodology

Affiliation Institute of Infectious Diseases, Shenzhen Bay Laboratory, Shenzhen, China
⨯
Xinyu Cao,

Roles Methodology, Project administration

Affiliation State Key Laboratory of Pathogen and Biosecurity, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China
⨯
Xiangyu Zhu,

Roles Software, Validation

Affiliation State Key Laboratory of Pathogen and Biosecurity, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China
⨯
Bocheng Liu,

Roles Investigation, Methodology

Affiliation State Key Laboratory of Pathogen and Biosecurity, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China
⨯
Qihui Yu,

Roles Project administration

Affiliation State Key Laboratory of Pathogen and Biosecurity, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China
⨯
Yuanyuan Li,

Roles Funding acquisition, Software

Affiliation State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, China
⨯
Hualei Wang,

Roles Funding acquisition, Project administration

Affiliation State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, China
⨯
Ningyi Jin ,

Roles Conceptualization, Project administration, Writing – review & editing

* E-mail: ningyik@126.com (NJ); huijun_lu@126.com (HL); shining17@jlu.edu.cn (NS)

Affiliations MOA Key Laboratory of Animal Virology, Zhejiang University Center for Veterinary Sciences, Hangzhou, China, State Key Laboratory of Pathogen and Biosecurity, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China
⨯
Huijun Lu ,

Roles Conceptualization, Project administration, Supervision

* E-mail: ningyik@126.com (NJ); huijun_lu@126.com (HL); shining17@jlu.edu.cn (NS)

Affiliations MOA Key Laboratory of Animal Virology, Zhejiang University Center for Veterinary Sciences, Hangzhou, China, State Key Laboratory of Pathogen and Biosecurity, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China

https://orcid.org/0000-0003-4532-4466

⨯
Ning Shi

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: ningyik@126.com (NJ); huijun_lu@126.com (HL); shining17@jlu.edu.cn (NS)

Affiliations State Key Laboratory of Pathogen and Biosecurity, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, China
⨯

The residue 86 of the Getah virus E2 glycoprotein mediates both glycosaminoglycan- and LDLR-dependent infection

Xiangshu Qiu,
Rongguang Lu,
Jiaxin Tian,
He Zhang,
Jiyong Zhou,
Mengsi Sun,
Xinyu Cao,
Xiangyu Zhu,
Bocheng Liu,
Qihui Yu

Published: July 31, 2026
https://doi.org/10.1371/journal.ppat.1014453

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