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Open Access
Peer-reviewed
Research Article
Differential assembly of RNP granules via activation of distinct dsRNA sensors by adenovirus mutants
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Robert T. Steinbock ,
Contributed equally to this work with: Robert T. Steinbock, Orlando B. Scudero
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing
Affiliations Division of Protective Immunity, and Division of Cancer Pathobiology, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Cell & Molecular Biology Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Orlando B. Scudero ,
Contributed equally to this work with: Robert T. Steinbock, Orlando B. Scudero
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing
Affiliation Division of Protective Immunity, and Division of Cancer Pathobiology, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
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Joseph M. Dybas,
Roles Data curation, Formal analysis, Methodology, Software, Visualization, Writing – review & editing
Affiliations Division of Protective Immunity, and Division of Cancer Pathobiology, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Center for Data-Driven Discovery in Biomedicine, Division of Neurosurgery, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
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Amber R. N. Abbott,
Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing
Affiliations Division of Protective Immunity, and Division of Cancer Pathobiology, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Cell & Molecular Biology Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Katarzyna Kulej,
Roles Data curation, Investigation, Methodology, Software, Validation, Visualization, Writing – review & editing
Current address: Tow Center for Developmental Oncology, Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
Affiliation Division of Protective Immunity, and Division of Cancer Pathobiology, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
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Richard Lauman,
Roles Data curation, Investigation, Methodology, Software, Writing – review & editing
Affiliation Division of Protective Immunity, and Division of Cancer Pathobiology, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
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Holly Chan,
Roles Investigation, Validation, Writing – review & editing
Affiliation Division of Protective Immunity, and Division of Cancer Pathobiology, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
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Eva L. Agostino,
Roles Investigation, Validation, Writing – review & editing
Affiliation Cell & Molecular Biology Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Namrata Kumar,
Roles Investigation, Validation, Visualization, Writing – review & editing
Affiliation Division of Protective Immunity, and Division of Cancer Pathobiology, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
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Cameron Stone,
Roles Formal analysis, Investigation, Validation, Writing – review & editing
Affiliation Division of Protective Immunity, and Division of Cancer Pathobiology, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
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Skyler Briggs,
Roles Investigation, Validation, Writing – review & editing
Affiliation Department of Molecular Medicine, The Herbert Wertheim University of Florida Scripps Institute for Biomedical Innovation and Technology, Jupiter, Florida, United States of America
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Nicholas A. Parenti,
Roles Resources, Writing – review & editing
Current address: Global Health Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
Affiliation Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Yize Li,
Roles Resources, Writing – review & editing
Current address: ASU-Banner Neurodegenerative Disease Reseach Center, Biodesign Institute, School Of Life Sciences Arizona State University, Tempe, Arizona, United States of America
Affiliation Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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James M. Burke,
Roles Conceptualization, Resources, Writing – review & editing
Affiliation Department of Molecular Medicine, The Herbert Wertheim University of Florida Scripps Institute for Biomedical Innovation and Technology, Jupiter, Florida, United States of America
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Susan R. Weiss,
Roles Conceptualization, Funding acquisition, Resources, Writing – review & editing
Affiliation Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Alexander M. Price ,
Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing
* E-mail: weitzmanm@chop.edu (MDW); aprice@wistar.edu (AMP)
Affiliation Genome Regulation and Cell Signaling, Ellen and Ronald Caplan Cancer Center, The Wistar Institute, Philadelphia, Pennsylvania, United States of America
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Matthew D. Weitzman
Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing
* E-mail: weitzmanm@chop.edu (MDW); aprice@wistar.edu (AMP)
Affiliations Division of Protective Immunity, and Division of Cancer Pathobiology, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Differential assembly of RNP granules via activation of distinct dsRNA sensors by adenovirus mutants
- Robert T. Steinbock,
- Orlando B. Scudero,
- Joseph M. Dybas,
- Amber R. N. Abbott,
- Katarzyna Kulej,
- Richard Lauman,
- Holly Chan,
- Eva L. Agostino,
- Namrata Kumar,
- Cameron Stone
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- Published: July 24, 2026
- https://doi.org/10.1371/journal.ppat.1014452