Salmonella effector kinase SteC is activated by phosphorylation at Serine 379

Timesh D. Pillay; Briac Lemetais; Jessica Huber; Ines Diaz del Olmo; Daniel Zhang; Yan Li; Laura Masino; Sarah Maslen; Mei Liu; Diego Esposito; Jay C. D. Hinton; Xiujun Yu; Teresa L. M. Thurston; Katrin Rittinger

doi:10.1371/journal.ppat.1014424

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Open Access

Peer-reviewed

Research Article

Salmonella effector kinase SteC is activated by phosphorylation at Serine 379

Timesh D. Pillay,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

Affiliations Molecular Structure of Cell Signalling Laboratory, The Francis Crick Institute, London, United Kingdom, Department of Infectious Disease, Centre for Bacterial Resistance Biology, Imperial College London, London, United Kingdom
⨯
Briac Lemetais,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Infectious Disease, Centre for Bacterial Resistance Biology, Imperial College London, London, United Kingdom
⨯
Jessica Huber,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Molecular Structure of Cell Signalling Laboratory, The Francis Crick Institute, London, United Kingdom
⨯
Ines Diaz del Olmo,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliations Department of Infectious Disease, Centre for Bacterial Resistance Biology, Imperial College London, London, United Kingdom, Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom, Bacterial Pathogenesis and Immune Signalling Laboratory, The Francis Crick Institute, London, United Kingdom
⨯
Daniel Zhang,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
⨯
Yan Li,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Clinical Infection, Microbiology and Immunology Department, Institute of Infection, Veterinary & Ecological Sciences, University of Liverpool, Liverpool, United Kingdom
⨯
Laura Masino,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Structural Biology Science Technology Platform, The Francis Crick Institute, London, United Kingdom
⨯
Sarah Maslen,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Proteomics Science Technology Platform, The Francis Crick Institute, London, United Kingdom
⨯
Mei Liu,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Infectious Disease, Centre for Bacterial Resistance Biology, Imperial College London, London, United Kingdom
⨯
Diego Esposito,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Molecular Structure of Cell Signalling Laboratory, The Francis Crick Institute, London, United Kingdom
⨯
Jay C. D. Hinton,

Roles Methodology, Supervision, Writing – review & editing

Affiliation Clinical Infection, Microbiology and Immunology Department, Institute of Infection, Veterinary & Ecological Sciences, University of Liverpool, Liverpool, United Kingdom
⨯
Xiujun Yu,

Roles Formal analysis, Investigation, Supervision, Writing – review & editing

Affiliation Department of Infectious Disease, Centre for Bacterial Resistance Biology, Imperial College London, London, United Kingdom
⨯
Teresa L. M. Thurston ,

Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – original draft, Writing – review & editing

* E-mail: teresa.thurston@path.ox.ac.uk (TLMT); katrin.rittinger@crick.ac.uk (KR)

Affiliations Department of Infectious Disease, Centre for Bacterial Resistance Biology, Imperial College London, London, United Kingdom, Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom, Bacterial Pathogenesis and Immune Signalling Laboratory, The Francis Crick Institute, London, United Kingdom
⨯
Katrin Rittinger

Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – original draft, Writing – review & editing

* E-mail: teresa.thurston@path.ox.ac.uk (TLMT); katrin.rittinger@crick.ac.uk (KR)

Affiliation Molecular Structure of Cell Signalling Laboratory, The Francis Crick Institute, London, United Kingdom

https://orcid.org/0000-0002-7698-4435

⨯

Salmonella effector kinase SteC is activated by phosphorylation at Serine 379

Timesh D. Pillay,
Briac Lemetais,
Jessica Huber,
Ines Diaz del Olmo,
Daniel Zhang,
Yan Li,
Laura Masino,
Sarah Maslen,
Mei Liu,
Diego Esposito

Published: July 16, 2026
https://doi.org/10.1371/journal.ppat.1014424

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Salmonella
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Phosphorylation
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Salmonellosis
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Actins
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Protein expression
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