Induction of neutralising antibodies against conserved rhinovirus capsid protein VP4 is dependent on presentation of VP4 peptide immunogens in a virus-like conformation

James T. Kelly; Giann Kerwin Y. Dellosa; Joseph Newman; Adel A. M. Mohamed; Julia Aniscenko; Sebastian L. Johnston; Jason Schnell; Tobias J. Tuthill

doi:10.1371/journal.ppat.1014416

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Open Access

Peer-reviewed

Research Article

Induction of neutralising antibodies against conserved rhinovirus capsid protein VP4 is dependent on presentation of VP4 peptide immunogens in a virus-like conformation

James T. Kelly ,

Contributed equally to this work with: James T. Kelly, Giann Kerwin Y. Dellosa

Roles Conceptualization, Formal analysis, Investigation, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: toby.tuthill@pirbright.ac.uk (TJT); james.kelly@pirbright.ac.uk (JTK)

Affiliation The Pirbright Institute, Pirbright, United Kingdom

https://orcid.org/0000-0002-8307-507X

⨯
Giann Kerwin Y. Dellosa ,

Contributed equally to this work with: James T. Kelly, Giann Kerwin Y. Dellosa

Roles Formal analysis, Investigation, Visualization, Writing – review & editing

Affiliation The Pirbright Institute, Pirbright, United Kingdom
⨯
Joseph Newman,

Roles Investigation, Writing – review & editing

Affiliation The Pirbright Institute, Pirbright, United Kingdom
⨯
Adel A. M. Mohamed,

Roles Investigation

Affiliation National Heart and Lung Institute, Imperial College London, London, United Kingdom
⨯
Julia Aniscenko,

Roles Investigation

Affiliation National Heart and Lung Institute, Imperial College London, London, United Kingdom
⨯
Sebastian L. Johnston,

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

Affiliation National Heart and Lung Institute, Imperial College London, London, United Kingdom
⨯
Jason Schnell,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Biochemistry, University of Oxford, Oxford, United Kingdom
⨯
Tobias J. Tuthill

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: toby.tuthill@pirbright.ac.uk (TJT); james.kelly@pirbright.ac.uk (JTK)

Affiliation The Pirbright Institute, Pirbright, United Kingdom
⨯

Induction of neutralising antibodies against conserved rhinovirus capsid protein VP4 is dependent on presentation of VP4 peptide immunogens in a virus-like conformation

James T. Kelly,
Giann Kerwin Y. Dellosa,
Joseph Newman,
Adel A. M. Mohamed,
Julia Aniscenko,
Sebastian L. Johnston,
Jason Schnell,
Tobias J. Tuthill

Published: July 16, 2026
https://doi.org/10.1371/journal.ppat.1014416

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