RNF31 restricts EV-A71 replication through innate immune activation and VP4 degradation, and is antagonized by viral 3C proteases

• Qingxiang Zhang ,

  Contributed equally to this work with: Qingxiang Zhang, Yuan Gao

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Institute of Virology and AIDS Research, Centre of Infectious Diseases and Pathogen Biology, Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, the First Hospital of Jilin University, Changchun, China

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• Yuan Gao ,

  Contributed equally to this work with: Qingxiang Zhang, Yuan Gao

  Roles Formal analysis, Investigation, Methodology, Software, Validation, Writing – original draft

  Affiliation Institute of Virology and AIDS Research, Centre of Infectious Diseases and Pathogen Biology, Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, the First Hospital of Jilin University, Changchun, China

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• Wenying Gao,

  Roles Conceptualization, Funding acquisition, Methodology, Validation

  Affiliation Institute of Virology and AIDS Research, Centre of Infectious Diseases and Pathogen Biology, Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, the First Hospital of Jilin University, Changchun, China

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• Xue Zhang,

  Roles Methodology, Software, Validation

  Affiliation Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, the Second Hospital of Jilin University, Changchun, China

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• Shengyuan Xu,

  Roles Validation

  Affiliation Institute of Virology and AIDS Research, Centre of Infectious Diseases and Pathogen Biology, Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, the First Hospital of Jilin University, Changchun, China

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• Wenyan Zhang

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: zhangwenyan@jlu.edu.cn

  Affiliation Institute of Virology and AIDS Research, Centre of Infectious Diseases and Pathogen Biology, Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, the First Hospital of Jilin University, Changchun, China

  https://orcid.org/0000-0003-4507-521X

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