Directed evolution of a stem-helix–targeting antibody enables MERS-CoV cross-neutralization through enhanced binding affinity

• Panpan Zhou ,

  Contributed equally to this work with: Panpan Zhou, Meng Yuan, Yuexiu Zhang, Oliver Limbo

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

  Present address: Shanghai Institute of Virology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

  Affiliations Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America, Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America

  ⨯
• Meng Yuan ,

  Contributed equally to this work with: Panpan Zhou, Meng Yuan, Yuexiu Zhang, Oliver Limbo

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America

  ⨯
• Yuexiu Zhang ,

  Contributed equally to this work with: Panpan Zhou, Meng Yuan, Yuexiu Zhang, Oliver Limbo

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  ⨯
• Oliver Limbo ,

  Contributed equally to this work with: Panpan Zhou, Meng Yuan, Yuexiu Zhang, Oliver Limbo

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America, Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America

  ⨯
• Ge Song,

  Roles Investigation, Writing – review & editing

  Affiliations Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America, Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America

  ⨯
• Fangzhu Zhao,

  Roles Methodology, Writing – review & editing

  Affiliations Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America, Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America

  ⨯
• Hejun Liu,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America

  ⨯
• Wan-ting He,

  Roles Investigation, Writing – review & editing

  Affiliations Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America, Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America

  ⨯
• Tazio Capozzola,

  Roles Investigation, Writing – review & editing

  Affiliations Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  ⨯
• Sean Callaghan,

  Roles Investigation, Writing – review & editing

  Affiliations Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America, Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America

  ⨯
• Gabriel Avillion,

  Roles Investigation, Writing – review & editing

  Affiliations Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America, Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America

  ⨯
• Xuduo Li,

  Roles Investigation, Writing – review & editing

  Affiliations Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  ⨯
• Nathan Beutler,

  Roles Resources, Writing – review & editing

  Affiliation Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America

  ⨯
• Peter Yong,

  Roles Investigation, Writing – review & editing

  Affiliations Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America, Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America

  ⨯
• Fabio Anzanello,

  Roles Investigation, Writing – review & editing

  Affiliations Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America, Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America

  ⨯
• Thomas F. Rogers,

  Roles Resources, Writing – review & editing

  Affiliations Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America, Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America, Division of Infectious Diseases, Department of Medicine, University of California, San Diego, La Jolla, California, United States of America

  ⨯
• Dennis R. Burton,

  Roles Methodology, Writing – review & editing

  Affiliations Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America, Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, Massachusetts, United States of America

  ⨯
• Joseph G. Jardine ,

  Roles Conceptualization, Methodology, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: jardine@scripps.edu (JGJ); wilson@scripps.edu (IAW); raiees.andrabi@pennmedicine.upenn.edu (RA)

  Affiliation Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America

  ⨯
• Ian A. Wilson ,

  Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: jardine@scripps.edu (JGJ); wilson@scripps.edu (IAW); raiees.andrabi@pennmedicine.upenn.edu (RA)

  Affiliations Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America, Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America

  ⨯
•  [ ... ],
• Raiees Andrabi

  Roles Conceptualization, Data curation, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: jardine@scripps.edu (JGJ); wilson@scripps.edu (IAW); raiees.andrabi@pennmedicine.upenn.edu (RA)

  Affiliations Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America, Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  https://orcid.org/0000-0001-8837-7520

  ⨯
• [ view all ]
• [ view less ]