Structural and functional characterization of a conserved cryptic epitope on SARS-CoV-2 spike S2 subunit

• Ling Zhou ,

  Roles Conceptualization, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

  ¶☯ These authors contributed equally to this manuscript.

  Affiliation Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, United States of America

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• Ching-Lin Hsieh ,

  Roles Conceptualization, Investigation, Validation, Visualization, Writing – review & editing

  ¶☯ These authors contributed equally to this manuscript.

  Affiliation Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, United States of America

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• Sarah R. Leist ,

  Roles Conceptualization, Investigation, Validation, Writing – original draft, Writing – review & editing

  ¶☯ These authors contributed equally to this manuscript.

  Affiliation Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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• Emily Happy Miller,

  Roles Conceptualization, Investigation, Validation, Writing – original draft, Writing – review & editing

  Affiliations Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America, Department of Medicine-Infectious Diseases, Albert Einstein College of Medicine, Bronx, New York, United States of America

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• Andrew P. Horton,

  Roles Conceptualization, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Pathology & Genomic Medicine, Antibody Discovery and Accelerated Protein Therapeutics, Houston Methodist Research Institute, Houston, Texas, United States of America

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• Sophie R. Shoemaker,

  Roles Conceptualization, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, United States of America

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• Elizabeth C. Gardner,

  Roles Conceptualization, Investigation, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, United States of America

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• John M. Powers,

  Roles Conceptualization, Investigation, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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• Daniel R. Boutz,

  Roles Conceptualization, Investigation, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Pathology & Genomic Medicine, Antibody Discovery and Accelerated Protein Therapeutics, Houston Methodist Research Institute, Houston, Texas, United States of America

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• Michael L. Mallory,

  Roles Conceptualization, Investigation, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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• Connor M. Mullins,

  Roles Investigation, Validation, Visualization, Writing – review & editing

  Affiliation Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, United States of America

  ⨯
• Nicole V. Johnson,

  Roles Investigation, Validation, Visualization, Writing – review & editing

  Affiliation Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, United States of America

  ⨯
• Alexandra L. Tse,

  Roles Conceptualization, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America

  ⨯
• Albert Wang,

  Roles Conceptualization, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America

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• Kamyab Javanmardi,

  Roles Conceptualization, Investigation, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, United States of America

  ⨯
• Lily E. Adams,

  Roles Conceptualization, Investigation, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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• Jonathan Schisler,

  Roles Conceptualization, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Department of Pathology & Lab Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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• Susan Marqusee,

  Roles Conceptualization, Funding acquisition, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliations Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, United States of America, Department of Chemistry, University of California, Berkeley, California, United States of America, Chan Zuckerberg Biohub, San Francisco, California, United States of America, California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, California, United States of America

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• Kartik Chandran,

  Roles Conceptualization, Funding acquisition, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America

  ⨯
• Ralph S. Baric,

  Roles Conceptualization, Funding acquisition, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

  ⨯
• Jimmy D. Gollihar,

  Roles Conceptualization, Funding acquisition, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Pathology & Genomic Medicine, Antibody Discovery and Accelerated Protein Therapeutics, Houston Methodist Research Institute, Houston, Texas, United States of America

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•  [ ... ],
• Jason S. McLellan

  Roles Conceptualization, Funding acquisition, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: jmclellan@austin.utexas.edu

  Affiliation Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, United States of America

  https://orcid.org/0000-0003-3991-542X

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