Engineered Lactobacillus paracasei 3×pBD1/ΔHLJ-27 as a novel antibiotic alternative for livestock: Dual efficacy in growth promotion and protection against Salmonella infection via integrated host-microbiota-immune regulation

• Yijie Yang ,

  Contributed equally to this work with: Yijie Yang, Ying Chen

  Roles Methodology, Writing – original draft

  Affiliation College of Veterinary Medicine, Northeast Agricultural University, Harbin, China

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• Ying Chen ,

  Contributed equally to this work with: Yijie Yang, Ying Chen

  Roles Methodology, Writing – original draft

  Affiliation College of Veterinary Medicine, Northeast Agricultural University, Harbin, China

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• Haiyuan Zhao,

  Roles Methodology, Writing – original draft

  Affiliation College of Veterinary Medicine, Northeast Agricultural University, Harbin, China

  ⨯
• Zhaojun Wang,

  Roles Resources

  Affiliation College of Veterinary Medicine, Northeast Agricultural University, Harbin, China

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• Meijun Yu,

  Roles Resources

  Affiliation College of Veterinary Medicine, Northeast Agricultural University, Harbin, China

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• Xijiao Shao,

  Roles Data curation, Software

  Affiliation College of Veterinary Medicine, Northeast Agricultural University, Harbin, China

  ⨯
• Yin Zhu,

  Roles Data curation, Software

  Affiliation College of Veterinary Medicine, Northeast Agricultural University, Harbin, China

  ⨯
• Ping Han,

  Roles Data curation, Software

  Affiliation College of Veterinary Medicine, Northeast Agricultural University, Harbin, China

  ⨯
• Tianyu Han,

  Roles Data curation, Software

  Affiliation College of Veterinary Medicine, Northeast Agricultural University, Harbin, China

  ⨯
• Wen Cui,

  Roles Project administration, Validation

  Affiliations College of Veterinary Medicine, Northeast Agricultural University, Harbin, China, Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Harbin, China

  ⨯
• Yanping Jiang,

  Roles Project administration, Validation

  Affiliations College of Veterinary Medicine, Northeast Agricultural University, Harbin, China, Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Harbin, China

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• Lijie Tang,

  Roles Formal analysis, Supervision, Visualization

  Affiliations College of Veterinary Medicine, Northeast Agricultural University, Harbin, China, Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Harbin, China

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• Yijing Li,

  Roles Formal analysis, Supervision, Visualization

  Affiliations College of Veterinary Medicine, Northeast Agricultural University, Harbin, China, Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Harbin, China

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• Jiaxuan Li ,

  Roles Conceptualization, Writing – review & editing

  * E-mail: xiaonawang0319@163.com (XW); lijiaxuan.1993@163.com (JL)

  Affiliations College of Veterinary Medicine, Northeast Agricultural University, Harbin, China, Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Harbin, China

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• Xiaona Wang

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  * E-mail: xiaonawang0319@163.com (XW); lijiaxuan.1993@163.com (JL)

  Affiliations College of Veterinary Medicine, Northeast Agricultural University, Harbin, China, Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Harbin, China

  https://orcid.org/0000-0002-5724-3025

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