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Open Access
Peer-reviewed
Research Article
Co-regulation of HIV control and cytomegalovirus pp65-specific IL-1β and TNF-α responses by genetic variants in the MHC region
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Suzanne D. E. Ruijten ,
Roles Formal analysis, Visualization, Writing – original draft
¶☯ These authors contributed equally to this study and share first authorship to this work.
Affiliation Department of Internal Medicine and Infectious Diseases, Radboudumc, Nijmegen, The Netherlands
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Jéssica C. dos Santos ,
Roles Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft
¶☯ These authors contributed equally to this study and share first authorship to this work.
Affiliation Department of Internal Medicine and Infectious Diseases, Radboudumc, Nijmegen, The Netherlands
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Victoria Rios-Vazquez,
Roles Formal analysis, Writing – review & editing
Affiliation Department of Internal Medicine and Infectious Diseases, Radboudumc, Nijmegen, The Netherlands
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Adriana Navas,
Roles Investigation, Writing – review & editing
Affiliation Department of Internal Medicine and Infectious Diseases, Radboudumc, Nijmegen, The Netherlands
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Hanneke Maas,
Roles Investigation, Writing – review & editing
Affiliation Department of Internal Medicine and Infectious Diseases, Radboudumc, Nijmegen, The Netherlands
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Albert L. Groenendijk,
Roles Investigation, Writing – review & editing
Affiliation Department of Internal Medicine and Department of Medical Microbiology and Infectious Diseases, ErasmusMC, Erasmus University, Rotterdam, The Netherlands
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Marc J. T. Blaauw,
Roles Investigation, Writing – review & editing
Affiliation Department of Internal Medicine and Infectious Diseases, Radboudumc, Nijmegen, The Netherlands
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Louise E. van Eekeren,
Roles Investigation, Writing – review & editing
Affiliation Department of Internal Medicine and Infectious Diseases, Radboudumc, Nijmegen, The Netherlands
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Wilhelm A. J. W. Vos,
Roles Investigation, Writing – review & editing
Affiliation Department of Internal Medicine and Infectious Diseases, Radboudumc, Nijmegen, The Netherlands
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Rainer Knoll,
Roles Data curation, Investigation, Writing – review & editing
Affiliation Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany
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Manoj Kumar Gupta,
Roles Data curation, Writing – review & editing
Affiliations Centre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany, TWINCORE, a joint venture between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany
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Rob ter Horst,
Roles Data curation, Writing – review & editing
Affiliation CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
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Javier Botey-Bataller,
Roles Data curation, Writing – review & editing
Affiliations Centre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany, TWINCORE, a joint venture between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany
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Nienke van Unen,
Roles Data curation, Writing – review & editing
Affiliations Centre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany, TWINCORE, a joint venture between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany, Cluster of Excellence Resolving Infection Susceptibility (RESIST; EXC 2155), Hannover Medical School, Hannover, Germany
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Yang Li,
Roles Data curation, Formal analysis, Supervision, Writing – review & editing
Affiliations Department of Internal Medicine and Infectious Diseases, Radboudumc, Nijmegen, The Netherlands, Centre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany, TWINCORE, a joint venture between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany, Cluster of Excellence Resolving Infection Susceptibility (RESIST; EXC 2155), Hannover Medical School, Hannover, Germany, Lower Saxony Center for Artificial Intelligence and Causal Methods in Medicine (CAIMed), Hannover, Germany
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Anna C. Aschenbrenner,
Roles Supervision, Writing – review & editing
Affiliation Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany
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Joachim L. Schultze,
Roles Supervision
Affiliations Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany, Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany
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Cheng-Jian Xu,
Roles Supervision, Writing – review & editing
Affiliations Centre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany, TWINCORE, a joint venture between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany
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Mihai G. Netea,
Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing
Affiliations Department of Internal Medicine and Infectious Diseases, Radboudumc, Nijmegen, The Netherlands, Department of Immunology and Metabolism, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany
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Andre J. A. M. van der Ven,
Roles Conceptualization, Supervision, Writing – review & editing
Affiliation Department of Internal Medicine and Infectious Diseases, Radboudumc, Nijmegen, The Netherlands
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Vasiliki Matzaraki
Roles Data curation, Formal analysis, Investigation, Supervision, Writing – original draft
* E-mail: vasiliki.matzaraki@radboudumc.nl
Affiliation Department of Internal Medicine and Infectious Diseases, Radboudumc, Nijmegen, The Netherlands
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Co-regulation of HIV control and cytomegalovirus pp65-specific IL-1β and TNF-α responses by genetic variants in the MHC region
- Suzanne D. E. Ruijten,
- Jéssica C. dos Santos,
- Victoria Rios-Vazquez,
- Adriana Navas,
- Hanneke Maas,
- Albert L. Groenendijk,
- Marc J. T. Blaauw,
- Louise E. van Eekeren,
- Wilhelm A. J. W. Vos,
- Rainer Knoll
- Published: July 14, 2026
- https://doi.org/10.1371/journal.ppat.1014355