Reduced inflammatory and Th1 transcriptional profiles in geriatric versus adult cotton rats infected with respiratory syncytial virus

Jonathan Miller; Cameron Leedale; Ayse Selen Yilmaz; Emily Pawlack; Jèssica Gómez Garrido; Tyler Alioto; Lianbo Yu; David E. Symer; Stefan Niewiesk

doi:10.1371/journal.ppat.1014323

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Open Access

Peer-reviewed

Research Article

Reduced inflammatory and Th1 transcriptional profiles in geriatric versus adult cotton rats infected with respiratory syncytial virus

Jonathan Miller ,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Writing – original draft

* E-mail: jonathan.miller2@wsu.edu

Affiliations Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio United States of America, Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, Washington United States of America

https://orcid.org/0009-0006-3777-8256

⨯
Cameron Leedale,

Roles Investigation

Affiliation Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio United States of America
⨯
Ayse Selen Yilmaz,

Roles Formal analysis

Affiliation Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, Ohio United States of America
⨯
Emily Pawlack,

Roles Investigation

Affiliation Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio United States of America
⨯
Jèssica Gómez Garrido,

Roles Resources

Affiliations Centro Nacional de Análisis Genómico (CNAG), Barcelona, Spain, Universitat de Barcelona (UB), Barcelona, Spain
⨯
Tyler Alioto,

Roles Resources

Affiliations Centro Nacional de Análisis Genómico (CNAG), Barcelona, Spain, Universitat de Barcelona (UB), Barcelona, Spain
⨯
Lianbo Yu,

Roles Formal analysis

Affiliation Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, Ohio United States of America
⨯
David E. Symer,

Roles Resources

Affiliation Division of Hematology and Oncology, Department of Medicine, VA Boston Healthcare System, US Department of Veterans Affairs, Boston, Massachusetts United States of America
⨯
Stefan Niewiesk

Roles Conceptualization, Methodology, Resources, Supervision, Writing – review & editing

Affiliation Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio United States of America
⨯

Reduced inflammatory and Th1 transcriptional profiles in geriatric versus adult cotton rats infected with respiratory syncytial virus

Jonathan Miller,
Cameron Leedale,
Ayse Selen Yilmaz,
Emily Pawlack,
Jèssica Gómez Garrido,
Tyler Alioto,
Lianbo Yu,
David E. Symer,
Stefan Niewiesk

Published: July 9, 2026
https://doi.org/10.1371/journal.ppat.1014323

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Geriatrics
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Inflammation
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Respiratory infections
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Cytokines
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Immune response
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Age groups
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Gene expression
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Viral gene expression
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