An orally available PfPKG inhibitor blocks Plasmodium’s infection of the liver

• Hanna Dhiyebi,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, New Jersey, United States of America

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• Aminata Mbaye,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, New Jersey, United States of America

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• Anusha Thaniana,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, New Jersey, United States of America

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• John Gilleran,

  Roles Investigation, Writing – review & editing

  Affiliation Rutgers Molecular Design and Synthesis Core, Office for Research, Rutgers University, Piscataway, New Jersey, United States of America

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• Tyler Eck,

  Roles Investigation

  Affiliation Department of Chemistry and Biochemistry and Sokol Institute of Pharmaceutical Life Sciences, Montclair State University, Montclair, New Jersey, United States of America

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• Kutub Ashraf,

  Roles Investigation

  Affiliations Department of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America, Integrated Pathogen Therapeutics Department, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America

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• Karl Kudyba,

  Roles Investigation

  Affiliations Department of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America, Integrated Pathogen Therapeutics Department, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America

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• Howard Fan,

  Roles Investigation

  Affiliation Division of Infectious Disease, Department of Medicine and Center for Data Science, Rutgers New Jersey Medical SchoolNewark, New JerseyUnited States of America

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• Steve Seibold,

  Roles Investigation

  Affiliations Seattle Children’s Center for Global infectious Disease Research, Seattle, Washington, United States of America, Protein Structure and X-ray Crystallography Laboratory, Del Shankel Structural Biology Center, University of Kansas, Lawrence, Kansas, United States of America

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• Kevin P. Battaile,

  Roles Investigation

  Affiliation New York Structural Biology Center, New York, New York, United States of America

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• John Siekierka,

  Roles Supervision

  Affiliation Department of Chemistry and Biochemistry and Sokol Institute of Pharmaceutical Life Sciences, Montclair State University, Montclair, New Jersey, United States of America

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• Evan Johnson,

  Roles Supervision

  Affiliation Division of Infectious Disease, Department of Medicine and Center for Data Science, Rutgers New Jersey Medical SchoolNewark, New JerseyUnited States of America

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• Alison Roth,

  Roles Supervision

  Affiliations Department of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America, Integrated Pathogen Therapeutics Department, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America

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• Amy De Rocher,

  Roles Investigation

  Affiliation Seattle Children’s Center for Global infectious Disease Research, Seattle, Washington, United States of America

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• Scott Lovell,

  Roles Investigation, Supervision

  Affiliations Seattle Children’s Center for Global infectious Disease Research, Seattle, Washington, United States of America, Protein Structure and X-ray Crystallography Laboratory, Del Shankel Structural Biology Center, University of Kansas, Lawrence, Kansas, United States of America

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• Edward B. Miller,

  Roles Investigation, Visualization

  Affiliation Schrödinger, Inc., New York, New York, United States of America

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• Jacques Y. Roberge,

  Roles Conceptualization, Formal analysis, Supervision, Writing – review & editing

  Affiliation Rutgers Molecular Design and Synthesis Core, Office for Research, Rutgers University, Piscataway, New Jersey, United States of America

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•  [ ... ],
• Purnima Bhanot

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: bhanotpu@njms.rutgers.edu

  Affiliation Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, New Jersey, United States of America

  https://orcid.org/0000-0001-5116-6973

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