A single Citrobacter rodentium infection in Pink1 knockout and wild-type mice leads to regional blood-brain-barrier perturbation and limited microglial activation without dopamine neuron axon terminal loss

Sriparna Mukherjee; Vladimir Grouza; Alex Tchung; Amandine Even; Moein Yaqubi; Marius Tuznik; Tyler Cannon; Sherilyn Junelle Recinto; Christina Gavino; Marie-Josée Bourque; Nicolas Giguère; Heidi McBride; Michel Desjardins; Samantha Gruenheid; Jo Anne Stratton; David A. Rudko; Louis-Eric Trudeau

doi:10.1371/journal.ppat.1014315

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Peer-reviewed

Research Article

A single Citrobacter rodentium infection in Pink1 knockout and wild-type mice leads to regional blood-brain-barrier perturbation and limited microglial activation without dopamine neuron axon terminal loss

Sriparna Mukherjee,

Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Visualization, Writing – original draft

Affiliations Department of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada, Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, Maryland, United States of America
⨯
Vladimir Grouza ,

Contributed equally to this work with: Vladimir Grouza, Alex Tchung, Amandine Even

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Writing – original draft

Affiliation Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal Neurological Institute, Montreal, Quebec, Canada
⨯
Alex Tchung ,

Contributed equally to this work with: Vladimir Grouza, Alex Tchung, Amandine Even

Roles Data curation, Formal analysis, Investigation, Methodology, Software

Affiliation Department of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada
⨯
Amandine Even ,

Contributed equally to this work with: Vladimir Grouza, Alex Tchung, Amandine Even

Roles Data curation, Formal analysis, Investigation, Methodology, Software

Affiliations Department of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada, Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, Maryland, United States of America
⨯
Moein Yaqubi,

Roles Data curation, Formal analysis, Investigation, Methodology, Software

Affiliations Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, Maryland, United States of America, Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal Neurological Institute, Montreal, Quebec, Canada
⨯
Marius Tuznik,

Roles Data curation, Investigation

Affiliation Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal Neurological Institute, Montreal, Quebec, Canada
⨯
Tyler Cannon,

Roles Data curation, Investigation

Affiliations Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, Maryland, United States of America, Department of Microbiology and Immunology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada
⨯
Sherilyn Junelle Recinto,

Roles Data curation, Investigation

Affiliations Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, Maryland, United States of America, Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal Neurological Institute, Montreal, Quebec, Canada
⨯
Christina Gavino,

Roles Data curation, Investigation

Affiliations Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, Maryland, United States of America, Department of Microbiology and Immunology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada
⨯
Marie-Josée Bourque,

Roles Data curation, Investigation

Affiliations Department of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada, Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, Maryland, United States of America
⨯
Nicolas Giguère,

Roles Formal analysis, Software

Affiliation Department of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada
⨯
Heidi McBride,

Roles Conceptualization, Funding acquisition

Affiliations Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, Maryland, United States of America, Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal Neurological Institute, Montreal, Quebec, Canada
⨯
Michel Desjardins,

Roles Funding acquisition

Affiliations Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, Maryland, United States of America, Department of Pathology and Cell Biology, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada
⨯
Samantha Gruenheid,

Roles Funding acquisition, Resources, Writing – review & editing

Affiliations Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, Maryland, United States of America, Department of Microbiology and Immunology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada
⨯
Jo Anne Stratton,

Roles Funding acquisition, Resources, Writing – review & editing

Affiliations Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, Maryland, United States of America, Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal Neurological Institute, Montreal, Quebec, Canada
⨯
David A. Rudko,

Roles Conceptualization, Funding acquisition, Resources, Writing – review & editing

Affiliation Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal Neurological Institute, Montreal, Quebec, Canada
⨯
[ ... ],
Louis-Eric Trudeau

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: louis-eric.trudeau@umontreal.ca

Affiliations Department of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada, Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, Maryland, United States of America, Department of Neurosciences, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada, Courtois Institute for Biomedical Innovation and SNC and CIRCA Research Groups, Université de Montréal, Montreal, Quebec, Canada

https://orcid.org/0000-0003-4684-1377

⨯
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A single Citrobacter rodentium infection in Pink1 knockout and wild-type mice leads to regional blood-brain-barrier perturbation and limited microglial activation without dopamine neuron axon terminal loss

Sriparna Mukherjee,
Vladimir Grouza,
Alex Tchung,
Amandine Even,
Moein Yaqubi,
Marius Tuznik,
Tyler Cannon,
Sherilyn Junelle Recinto,
Christina Gavino,
Marie-Josée Bourque

Published: June 30, 2026
https://doi.org/10.1371/journal.ppat.1014315

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