Chemo-omic pipeline enables discovery of prion synaptotoxic pathways and inhibitory drugs

• Nhat T. T. Le,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Department of Cancer Biology and Genetics, College of Medicine, The Ohio State University Columbus, Ohio, United States of America

  Affiliation Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, United States of America

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• Robert C. C. Mercer,

  Roles Conceptualization, Investigation, Methodology, Visualization, Writing – review & editing

  Department of Biochemistry & Molecular Genetics, College of Graduate Studies, Midwestern University, Glendale, Arizona, United States of America

  Affiliation Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0001-6029-511X

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• Cheng Fang,

  Roles Investigation, Methodology

  Annovis Bio Inc., Malvern, Pennsylvania, United States of America

  Affiliation Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, United States of America

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• Aravind Sundaravadivelu,

  Roles Formal analysis

  Center for RNA Therapeutics, Houston Methodist Research Institute, Houston, Texas, United States of America

  Affiliation Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, United States of America

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• Adam T. Labadorf,

  Roles Formal analysis

  Affiliation Bioinformatics Program, Boston University, Boston, Massachusetts, United States of America

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• Weiwei Lin,

  Roles Formal analysis, Writing – review & editing

  Affiliation Department of Pharmacology, Physiology and Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, United States of America

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• Julian Kwan,

  Roles Formal analysis, Investigation

  Affiliation Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, United States of America

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• Benjamin Blum,

  Roles Formal analysis, Software, Visualization

  Affiliation Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, United States of America

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• Andrew Emili,

  Roles Conceptualization, Funding acquisition

  Department of Biomedical Engineering, Division of Oncological Sciences, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, United States of America

  Affiliation Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, United States of America

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• David A. Harris

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: daharris@bu.edu

  Affiliation Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0002-6985-5790

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