A rotavirus vaccine candidate attenuated by codon deoptimization protects neonatal mice against wild-type virus infection

• Zelin Chen,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Virology, Research Institute for Microbial Diseases, The University of Osaka, Osaka, Japan

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• Tomohiro Kotaki ,

  Roles Conceptualization, Funding acquisition, Investigation, Supervision, Validation, Writing – review & editing

  * E-mail: tkotaki@biken.osaka-u.ac.jp (TK); tkobayashi@biken.osaka-u.ac.jp (TK)

  Affiliation Department of Virology, Research Institute for Microbial Diseases, The University of Osaka, Osaka, Japan

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• Daisuke Motooka,

  Roles Investigation, Writing – review & editing

  Affiliation NGS Core Facility, Research Institute for Microbial Diseases, The University of Osaka, Osaka, Japan

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• Shintaro Sato,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Department of Microbiology and Immunology, School of Pharmaceutical Sciences, Wakayama Medical University, Wakayama, Japan

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• Yusuke Sakai,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Infectious Disease Pathology, National Institute of Infectious Diseases, Japan Institute for Health Security, Tokyo, Japan

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• Katsuhisa Hirai,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Virology, Research Institute for Microbial Diseases, The University of Osaka, Osaka, Japan

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• Shohei Minami,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Virology, Research Institute for Microbial Diseases, The University of Osaka, Osaka, Japan

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• Takahiro Kawagishi,

  Roles Investigation, Writing – review & editing

  Affiliations Department of Virology, Research Institute for Microbial Diseases, The University of Osaka, Osaka, Japan, Center for Advanced Modalities and DDS, The University of Osaka, Osaka, Japan

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• Yuta Kanai,

  Roles Funding acquisition, Investigation, Supervision, Writing – review & editing

  Affiliation Department of Virology, Research Institute for Microbial Diseases, The University of Osaka, Osaka, Japan

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• Takeshi Kobayashi

  Roles Conceptualization, Funding acquisition, Investigation, Supervision, Validation, Writing – review & editing

  * E-mail: tkotaki@biken.osaka-u.ac.jp (TK); tkobayashi@biken.osaka-u.ac.jp (TK)

  Affiliations Department of Virology, Research Institute for Microbial Diseases, The University of Osaka, Osaka, Japan, Center for Advanced Modalities and DDS, The University of Osaka, Osaka, Japan, Center for Infectious Disease Education and Research, The University of Osaka, Osaka, Japan

  https://orcid.org/0000-0002-5532-207X

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