A designed peptide disrupting viral protease cleavage restores cGAS-DNA phase separation and type I interferon responses

• Hongyan Yin ,

  Contributed equally to this work with: Hongyan Yin, Zhenchao Zhao

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft

  Affiliation State Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China

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• Zhenchao Zhao ,

  Contributed equally to this work with: Hongyan Yin, Zhenchao Zhao

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Visualization

  Affiliation State Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China

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• Haiwei Wang ,

  Roles Resources

  * E-mail: wanghaiwei@caas.cn (HW); xinl@jlu.edu.cn (XL)

  Affiliation State Key Laboratory of Animal Disease Control, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

  https://orcid.org/0000-0002-0588-2511

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• Xin Li

  Roles Conceptualization, Data curation, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: wanghaiwei@caas.cn (HW); xinl@jlu.edu.cn (XL)

  Affiliations State Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China, Department of Respiratory Medicine, Center of Infectious Diseases and Pathogen Biology, Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, The First Hospital of Jilin University, Changchun, China

  https://orcid.org/0000-0003-1636-8910

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