HIV-1 BG505 SOSIP immunization induced B cell expansion targeting the 465-glycan hole, with neutralizing antibodies exhibiting distinct binding modes and mechanisms of virus inhibition

• August Myers ,

  Contributed equally to this work with: August Myers, Monika Chandravanshi

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America

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• Monika Chandravanshi ,

  Contributed equally to this work with: August Myers, Monika Chandravanshi

  Roles Data curation, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, United States of America

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• Leanne S. Whitmore,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America, Washington National Biomedical Research Center, University of Washington, Seattle, Washington, United States of America

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• Brendan F. Kohrn,

  Roles Methodology, Writing – review & editing

  Affiliation Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America

  ⨯
• Amina Negash,

  Roles Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America

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• Dung N. Nguyen,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliations Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, United States of America

  ⨯
• Pooja Ralli-Jain,

  Roles Investigation, Validation, Writing – review & editing

  Affiliation Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America

  ⨯
• Kendra Cruickshank,

  Roles Investigation, Validation, Writing – review & editing

  Affiliation Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America

  ⨯
• Amit A. Upadhyay,

  Roles Methodology, Writing – review & editing

  Affiliations Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America

  ⨯
• Tysheena Charles,

  Roles Conceptualization, Resources, Writing – review & editing

  Affiliations Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America, Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, United States of America

  ⨯
• Christopher T. Edwards,

  Roles Methodology, Writing – review & editing

  Affiliations Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America

  ⨯
• Eric Hunter,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliations Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America

  ⨯
• Rama R. Amara,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliations Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America, Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, United States of America

  ⨯
• Marek K. Korzeniowski,

  Roles Writing – review & editing

  Affiliations Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, United States of America

  ⨯
• Ling Niu,

  Roles Resources, Writing – review & editing

  Affiliations Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, United States of America

  ⨯
• Edwin Pozharski,

  Roles Investigation, Resources, Writing – review & editing

  Affiliations Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland, United States of America, Institute for Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, Maryland, United States of America

  ⨯
• William D. Tolbert,

  Roles Data curation, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, United States of America

  ⨯
• Steven E. Bosinger,

  Roles Conceptualization, Methodology, Resources, Supervision, Writing – review & editing

  Affiliations Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America

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• Scott R. Kennedy,

  Roles Methodology, Supervision, Writing – review & editing

  Affiliation Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America

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• Marzena Pazgier ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: cderde@uw.edu (CAD); marzena.pazgier@usuhs.edu (MP)

  Affiliation Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America

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•  [ ... ],
• Cynthia A. Derdeyn

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: cderde@uw.edu (CAD); marzena.pazgier@usuhs.edu (MP)

  Affiliations Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America, Washington National Biomedical Research Center, University of Washington, Seattle, Washington, United States of America

  https://orcid.org/0000-0002-1220-513X

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