PrP turnover in vivo and the time to effect of prion disease therapeutics

• Taylor L. Corridon,

  Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Program in Brain Health, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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• Jill O’Moore,

  Roles Investigation, Writing – review & editing

  Affiliation Weissman Hood Institute, Great Falls, Montana, United States of America

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• Alyssa Seerley,

  Roles Investigation, Writing – review & editing

  Affiliation Weissman Hood Institute, Great Falls, Montana, United States of America

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• Daniel A. Sprague,

  Roles Formal analysis, Writing – original draft, Writing – review & editing

  Affiliation Program in Brain Health, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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• Yuan Lian,

  Roles Formal analysis, Writing – review & editing

  Affiliation Program in Brain Health, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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• Vanessa Laversenne,

  Roles Investigation, Writing – review & editing

  Affiliation Program in Brain Health, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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• Briana Noble,

  Roles Investigation, Writing – review & editing

  Affiliation Ionis Pharmaceuticals, Carlsbad, California, United States of America

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• Nikita G. Kamath,

  Roles Investigation, Writing – review & editing

  Affiliation Program in Brain Health, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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• Fiona E. Serack,

  Roles Investigation, Writing – review & editing

  Affiliation Program in Brain Health, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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• Abdul Basit Shaikh,

  Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Charles River Laboratories, Worcester, Massachusetts, United States of America

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• Brian Erickson,

  Roles Conceptualization, Investigation, Writing – review & editing

  Affiliation IQ Proteomics, Framingham, Massachusetts, United States of America

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• Craig Braun,

  Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation IQ Proteomics, Framingham, Massachusetts, United States of America

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• Kendrick DeSouza-Lenz,

  Roles Investigation, Writing – review & editing

  Affiliation Comparative Medicine, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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• Michael Howard,

  Roles Investigation, Writing – review & editing

  Affiliation Comparative Medicine, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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• Nathan Chan,

  Roles Investigation, Writing – review & editing

  Affiliation Comparative Medicine, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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• Walker S. Jackson,

  Roles Conceptualization, Writing – review & editing

  Affiliation Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden

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• Andrew G. Reidenbach,

  Roles Conceptualization, Investigation, Writing – review & editing

  Current address: Magnet Biomedicine, Boston, Massachusetts, United States of America

  Affiliation Program in Brain Health, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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• Deborah E. Cabin,

  Roles Investigation, Writing – review & editing

  Affiliation Weissman Hood Institute, Great Falls, Montana, United States of America

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• Sonia M. Vallabh,

  Roles Conceptualization, Writing – review & editing

  Affiliations Program in Brain Health, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, McCance Center for Brain Health and Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Neurology, Harvard Medical School, Boston, Massachusetts, United States of America, Prion Alliance, Cambridge, Massachusetts, United States of America

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• Andrea Grindeland Panter,

  Roles Conceptualization, Writing – review & editing

  Affiliation Weissman Hood Institute, Great Falls, Montana, United States of America

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• Nina Oberbeck,

  Roles Conceptualization, Formal analysis, Writing – review & editing

  Affiliation Gate Bio, Brisbane, California, United States of America

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• Hien T. Zhao,

  Roles Conceptualization, Formal analysis, Writing – review & editing

  Affiliation Ionis Pharmaceuticals, Carlsbad, California, United States of America

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•  [ ... ],
• Eric Vallabh Minikel

  Roles Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing

  * E-mail: eminikel@broadinstitute.org

  Affiliations Program in Brain Health, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, McCance Center for Brain Health and Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Neurology, Harvard Medical School, Boston, Massachusetts, United States of America, Prion Alliance, Cambridge, Massachusetts, United States of America

  https://orcid.org/0000-0003-2206-1608

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