Outer membrane vesicles hijack TIM-1 for cellular uptake

Craig R. MacNair; Varnesh Tiku; Shengya Cao; Ariana D. Sanchez; Barath Udayasuryan; Katharina Theresa Kroll; Adarsh Singh; Man-Wah Tan

doi:10.1371/journal.ppat.1014256

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Open Access

Peer-reviewed

Research Article

Outer membrane vesicles hijack TIM-1 for cellular uptake

Craig R. MacNair,

Roles Conceptualization, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

Affiliation Infectious Diseases and Host-Microbe Interactions Department, Genentech Inc., San Francisco, California, United States of America

https://orcid.org/0000-0002-3558-438X

⨯
Varnesh Tiku,

Roles Conceptualization, Investigation, Writing – review & editing

Affiliations Infectious Diseases and Host-Microbe Interactions Department, Genentech Inc., San Francisco, California, United States of America, Department of Oncology, Gilead Sciences Inc., Foster City, California, United States of America
⨯
Shengya Cao,

Roles Investigation, Methodology, Writing – review & editing

Affiliations Microchemistry, Proteomics and Lipidomics, Genentech, San Francisco, California, United States of America, S.C. Translation, Inceptive, Palo Alto, California, United States of America
⨯
Ariana D. Sanchez,

Roles Investigation, Writing – review & editing

Affiliation Microchemistry, Proteomics and Lipidomics, Genentech, San Francisco, California, United States of America
⨯
Barath Udayasuryan,

Roles Investigation, Writing – review & editing

Affiliation Infectious Diseases and Host-Microbe Interactions Department, Genentech Inc., San Francisco, California, United States of America
⨯
Katharina Theresa Kroll,

Roles Investigation, Writing – review & editing

Affiliation Infectious Diseases and Host-Microbe Interactions Department, Genentech Inc., San Francisco, California, United States of America
⨯
Adarsh Singh,

Roles Investigation, Writing – review & editing

Affiliations Infectious Diseases and Host-Microbe Interactions Department, Genentech Inc., San Francisco, California, United States of America, Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York, United States of America
⨯
Man-Wah Tan

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: tan.man-wah@gene.com

Affiliation Infectious Diseases and Host-Microbe Interactions Department, Genentech Inc., San Francisco, California, United States of America

https://orcid.org/0000-0002-7748-212X

⨯

Outer membrane vesicles hijack TIM-1 for cellular uptake

Craig R. MacNair,
Varnesh Tiku,
Shengya Cao,
Ariana D. Sanchez,
Barath Udayasuryan,
Katharina Theresa Kroll,
Adarsh Singh,
Man-Wah Tan

Published: May 26, 2026
https://doi.org/10.1371/journal.ppat.1014256
See the preprint

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