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Open Access
Peer-reviewed
Research Article
HCMV-pUS2 Disrupts cGAS-STING Signaling through LMAN2L Degradation
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Yue-Peng Zhou ,
Contributed equally to this work with: Yue-Peng Zhou, Yong-Xuan Yao, Jin-Peng Wu
Roles Formal analysis, Funding acquisition, Investigation, Methodology
Affiliations State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China, State Key Laboratory of Magnetic Resonance Spectroscopy and Imaging, National Center for Magnetic Resonance in Wuhan, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, China
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Yong-Xuan Yao ,
Contributed equally to this work with: Yue-Peng Zhou, Yong-Xuan Yao, Jin-Peng Wu
Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation
Affiliation Department of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangdong Provincial Children’s Medical Research Center, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China
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Jin-Peng Wu ,
Contributed equally to this work with: Yue-Peng Zhou, Yong-Xuan Yao, Jin-Peng Wu
Roles Investigation
Affiliations State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China
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Yu-Ting Pan,
Roles Validation
Affiliations State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China
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Wen-Bo Zeng,
Roles Funding acquisition, Methodology, Resources
Affiliations State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China
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Jin-Yan Sun,
Roles Methodology, Resources
Affiliation State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China
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Yue Zhao,
Roles Investigation, Validation
Affiliation State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China
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Han Cheng ,
Roles Funding acquisition, Writing – review & editing
* E-mail: yangbo2022@wh.iov.cn (BY), luomh@wh.iov.cn (MHL), chenghan@shaphc.org.cn (HC)
Affiliation Shanghai Public Health Clinical Center, Fudan University, Shanghai, China
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Min-Hua Luo ,
Roles Funding acquisition, Supervision, Writing – review & editing
* E-mail: yangbo2022@wh.iov.cn (BY), luomh@wh.iov.cn (MHL), chenghan@shaphc.org.cn (HC)
Affiliations State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China, State Key Laboratory of Magnetic Resonance Spectroscopy and Imaging, National Center for Magnetic Resonance in Wuhan, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, China, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China
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Bo Yang
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing
* E-mail: yangbo2022@wh.iov.cn (BY), luomh@wh.iov.cn (MHL), chenghan@shaphc.org.cn (HC)
Affiliations State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China
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HCMV-pUS2 Disrupts cGAS-STING Signaling through LMAN2L Degradation
- Yue-Peng Zhou,
- Yong-Xuan Yao,
- Jin-Peng Wu,
- Yu-Ting Pan,
- Wen-Bo Zeng,
- Jin-Yan Sun,
- Yue Zhao,
- Han Cheng,
- Min-Hua Luo,
- Bo Yang
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- Published: May 18, 2026
- https://doi.org/10.1371/journal.ppat.1014246