A novel penicillin-binding protein inhibitor with unprecedented intracellular activity eradicates multiple pathogenic bacteria

• Kai-Xuan Guo,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China

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• Hong-Xia Hu,

  Roles Conceptualization, Investigation, Writing – original draft, Writing – review & editing

  Affiliation National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China

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• Zhen Cheng,

  Roles Conceptualization, Investigation, Writing – review & editing

  Affiliation National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China

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• Jian-Dong Zhang,

  Roles Formal analysis, Writing – review & editing

  Affiliation National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China

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• Feng-Dong Zhu,

  Roles Formal analysis

  Affiliation National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China

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• Ying-Lei Zhang,

  Roles Formal analysis

  Affiliation National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China

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• Chao-Yue Guo,

  Roles Investigation

  Affiliation National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China

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• Kai-Xin Wu,

  Roles Investigation

  Affiliation National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China

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• Guo-Hua Cai,

  Roles Investigation

  Affiliation National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China

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• Hong-Rong Hong,

  Roles Methodology

  Affiliation National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China

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• Xiao-Yu Wan,

  Roles Methodology

  Affiliation National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China

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• Xu Yan,

  Roles Methodology

  Affiliation National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China

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• Wei Chen,

  Roles Methodology

  Affiliation National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China

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• Xuan Liang,

  Roles Methodology

  Affiliation National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China

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• Long-Chuan Duan,

  Roles Methodology

  Affiliation National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China

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• Huan-Chun Chen,

  Roles Resources

  Affiliations The Cooperative Innovation Center for Sustainable Pig Production, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China, Key Laboratory of the Development of Veterinary Diagnostic Products, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China

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•  [ ... ],
• Zheng-Fei Liu

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: lzf6789@mail.hzau.edu.cn

  Affiliations National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China, The Cooperative Innovation Center for Sustainable Pig Production, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China, Key Laboratory of the Development of Veterinary Diagnostic Products, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China, Hongshan Laboratory, Wuhan, China

  https://orcid.org/0000-0002-0888-1987

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