LP.8.1-directed COVID-19 mRNA vaccines durably boost neutralizing antibodies and mitigate ancestral immune imprinting

• Ian A. Mellis ,

  Contributed equally to this work with: Ian A. Mellis, Madeline Wu, Hsiang Hong

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: im2613@cumc.columbia.edu (IAM); gordonal@umich.edu (AG); yg2521@cumc.columbia.edu (YG); dh2994@cumc.columbia.edu (DDH)

  Affiliations Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, United States of America, Department of Pathology and Cell Biology, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, United States of America

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• Madeline Wu ,

  Contributed equally to this work with: Ian A. Mellis, Madeline Wu, Hsiang Hong

  Roles Data curation, Formal analysis, Investigation, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, United States of America

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• Hsiang Hong ,

  Contributed equally to this work with: Ian A. Mellis, Madeline Wu, Hsiang Hong

  Roles Data curation, Formal analysis, Investigation, Project administration, Validation, Writing – original draft, Writing – review & editing

  Affiliations Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, United States of America, Department of Microbiology, National Taiwan University College of Medicine, Taipei, Taiwan

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• Anthony Bowen,

  Roles Funding acquisition, Investigation, Resources

  Affiliations Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, United States of America, Division of Infectious Diseases, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, United States of America

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• Kristin Daniel,

  Roles Investigation, Validation

  Affiliations Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, United States of America, Department of Pathology and Cell Biology, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, United States of America

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• Carmen Gherasim,

  Roles Resources

  Affiliation Department of Pathology, University of Michigan, Ann Arbor, Michigan, United States of America

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• Virginia M. Pierce,

  Roles Resources

  Affiliation Department of Pathology, University of Michigan, Ann Arbor, Michigan, United States of America

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• Michael T. Yin,

  Roles Funding acquisition, Resources

  Affiliations Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, United States of America, Division of Infectious Diseases, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, United States of America

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• Aubree Gordon ,

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Writing – review & editing

  * E-mail: im2613@cumc.columbia.edu (IAM); gordonal@umich.edu (AG); yg2521@cumc.columbia.edu (YG); dh2994@cumc.columbia.edu (DDH)

  Affiliation Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, United States of America

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• Yicheng Guo ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: im2613@cumc.columbia.edu (IAM); gordonal@umich.edu (AG); yg2521@cumc.columbia.edu (YG); dh2994@cumc.columbia.edu (DDH)

  Affiliation Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, United States of America

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• David D. Ho

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: im2613@cumc.columbia.edu (IAM); gordonal@umich.edu (AG); yg2521@cumc.columbia.edu (YG); dh2994@cumc.columbia.edu (DDH)

  ¶‡ Lead contact.

  Affiliations Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, United States of America, Division of Infectious Diseases, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, United States of America, Department of Microbiology and Immunology, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, United States of America, Pandemic Research Alliance unit at the Wu Center for Pandemic Research, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, United States of America

  https://orcid.org/0000-0003-1627-149X

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