Spatiotemporal dynamics of signal dependent exocytosis and parasitophorous vacuolar membrane rupture during Plasmodium falciparum egress

Watcharatip Dedkhad; Tia Tran; Manuel A. Fierro; Carrie Brooks; Vasant Muralidharan

doi:10.1371/journal.ppat.1014214

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Peer-reviewed

Research Article

Spatiotemporal dynamics of signal dependent exocytosis and parasitophorous vacuolar membrane rupture during Plasmodium falciparum egress

Watcharatip Dedkhad,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Visualization, Writing – original draft, Writing – review & editing

Affiliations Center for Tropical and Emerging Global Diseases, Athens, Georgia, United States of America, Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America

https://orcid.org/0000-0003-3850-0142

⨯
Tia Tran,

Roles Investigation, Validation

Current address: Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America

Affiliations Center for Tropical and Emerging Global Diseases, Athens, Georgia, United States of America, Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America
⨯
Manuel A. Fierro,

Roles Conceptualization, Investigation, Methodology

Current address: Department of Genetics and Biochemistry, Eukaryotic Pathogen Innovation Center, Clemson University, Clemson, South Carolina, United States of America

Affiliations Center for Tropical and Emerging Global Diseases, Athens, Georgia, United States of America, Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America

https://orcid.org/0000-0001-8729-5945

⨯
Carrie Brooks,

Roles Data curation, Investigation, Methodology, Supervision, Validation

Affiliation Center for Tropical and Emerging Global Diseases, Athens, Georgia, United States of America
⨯
Vasant Muralidharan

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: vasant@uga.edu

Affiliations Center for Tropical and Emerging Global Diseases, Athens, Georgia, United States of America, Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America

https://orcid.org/0000-0001-6367-6284

⨯

Spatiotemporal dynamics of signal dependent exocytosis and parasitophorous vacuolar membrane rupture during Plasmodium falciparum egress

Watcharatip Dedkhad,
Tia Tran,
Manuel A. Fierro,
Carrie Brooks,
Vasant Muralidharan

Published: May 11, 2026
https://doi.org/10.1371/journal.ppat.1014214

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Exocytosis
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Merozoites
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Vesicles
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Calcium signaling
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Fluorescence imaging
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Plasmodium
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Parasitic diseases
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