Host species-specific mutations in the thumb domain of the 3D^pol polymerase are required for efficient replication of human hepatitis A virus in mice

• Ichiro Misumi ,

  Contributed equally to this work with: Ichiro Misumi, Takayoshi Shirasaki

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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• Takayoshi Shirasaki ,

  Contributed equally to this work with: Ichiro Misumi, Takayoshi Shirasaki

  Roles Investigation, Writing – review & editing

  Affiliation Department of Microbiology & Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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• Ling Xie,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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• Bryan Yonish,

  Roles Investigation, Writing – review & editing

  Affiliation Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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• Olga González-López,

  Roles Investigation, Writing – review & editing

  Current address: BioAgilytix, Morrisville, North Carolina, USA

  Affiliation Department of Microbiology & Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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• Asuka Hirai-Yuki,

  Roles Conceptualization, Investigation, Writing – review & editing

  Current address: Research Center for Biosafety, Laboratory Animal and Pathogen Bank, National Institute of Infectious Diseases, Japan Institute for Health Security, Tokyo, Japan

  Affiliation Department of Microbiology & Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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• Xian Chen,

  Roles Resources, Supervision

  Affiliations Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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• You Li,

  Roles Funding acquisition, Investigation, Writing – review & editing

  Affiliation Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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• Jason K. Whitmire,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Department of Microbiology & Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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• Stanley M. Lemon

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * smlemon@med.unc.edu

  Affiliations Department of Microbiology & Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

  https://orcid.org/0000-0003-1450-806X

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