SPRY domains encode ubiquitin ligase specificity for ZAP and RIG-I

Ibrahim Syed; Sheng Chen; David J. Peeler; Paul F. McKay; Marco A. Briones-Orta; Jennifer A. Bohn; Robin J. Shattock; Daniel Gonçalves-Carneiro

doi:10.1371/journal.ppat.1014195

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Open Access

Peer-reviewed

Research Article

SPRY domains encode ubiquitin ligase specificity for ZAP and RIG-I

Ibrahim Syed,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, United Kingdom
⨯
Sheng Chen,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, United Kingdom
⨯
David J. Peeler,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliations Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, United Kingdom, Department of Physiology, Anatomy and Genetics, Department of Engineering Science, Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, United Kingdom
⨯
Paul F. McKay,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, United Kingdom
⨯
Marco A. Briones-Orta,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, United Kingdom
⨯
Jennifer A. Bohn,

Roles Formal analysis, Writing – review & editing

Affiliation RockEDU Science Outreach, The Rockefeller University, New York, New York, United States of America
⨯
Robin J. Shattock,

Roles Formal analysis, Funding acquisition, Supervision

Affiliation Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, United Kingdom
⨯
Daniel Gonçalves-Carneiro

Roles Formal analysis, Funding acquisition, Investigation, Supervision, Writing – original draft, Writing – review & editing

* E-mail: d.goncalves-carneiro@imperial.ac.uk

Affiliation Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, United Kingdom

https://orcid.org/0000-0002-9333-1540

⨯

SPRY domains encode ubiquitin ligase specificity for ZAP and RIG-I

Ibrahim Syed,
Sheng Chen,
David J. Peeler,
Paul F. McKay,
Marco A. Briones-Orta,
Jennifer A. Bohn,
Robin J. Shattock,
Daniel Gonçalves-Carneiro

Published: May 8, 2026
https://doi.org/10.1371/journal.ppat.1014195

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Transfection
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Protein interactions
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Small interfering RNA
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Protein domains
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Luciferase
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Protein structure prediction
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Ubiquitin ligases
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Co-immunoprecipitation
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