MCL1 promotes porcine epidemic diarrhea virus replication by modulating arachidonic acid metabolic pathway

Hongqi Shang; Shanshan Yang; Min Sun; Yongxiang Zhao; Rongli Guo; Wei Wang; Bingxu Qian; Yunchuan Li; Mi Hu; Xianyu Bian; Qiuxia Cao; Chengcheng Li; Baochao Fan; Bin Li

doi:10.1371/journal.ppat.1014170

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Open Access

Peer-reviewed

Research Article

MCL1 promotes porcine epidemic diarrhea virus replication by modulating arachidonic acid metabolic pathway

Hongqi Shang,

Roles Data curation, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Nanjing, China, Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base of Ministry of Science and Technology, Nanjing, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China
⨯
Shanshan Yang,

Roles Formal analysis, Investigation

Affiliations Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Nanjing, China, Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base of Ministry of Science and Technology, Nanjing, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China
⨯
Min Sun,

Roles Formal analysis, Investigation

Affiliations Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Nanjing, China, Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base of Ministry of Science and Technology, Nanjing, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China
⨯
Yongxiang Zhao,

Roles Investigation

Affiliations Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Nanjing, China, Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base of Ministry of Science and Technology, Nanjing, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China, GuoTai (Taizhou) Center of Technology Innovation for Veterinary Biologicals, Taizhou, China
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Rongli Guo,

Roles Methodology

Affiliations Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Nanjing, China, Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base of Ministry of Science and Technology, Nanjing, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China, GuoTai (Taizhou) Center of Technology Innovation for Veterinary Biologicals, Taizhou, China
⨯
Wei Wang,

Roles Methodology

Affiliations Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Nanjing, China, Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base of Ministry of Science and Technology, Nanjing, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China
⨯
Bingxu Qian,

Roles Validation

Affiliations Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Nanjing, China, Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base of Ministry of Science and Technology, Nanjing, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China
⨯
Yunchuan Li,

Roles Visualization

Affiliations Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Nanjing, China, Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base of Ministry of Science and Technology, Nanjing, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China
⨯
Mi Hu,

Roles Formal analysis

Affiliations Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Nanjing, China, Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base of Ministry of Science and Technology, Nanjing, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China
⨯
Xianyu Bian,

Roles Visualization

Affiliations Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Nanjing, China, Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base of Ministry of Science and Technology, Nanjing, China
⨯
Qiuxia Cao,

Roles Validation

Affiliations Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Nanjing, China, Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base of Ministry of Science and Technology, Nanjing, China
⨯
Chengcheng Li,

Roles Validation

Affiliations Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Nanjing, China, Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base of Ministry of Science and Technology, Nanjing, China
⨯
Baochao Fan ,

Roles Conceptualization, Data curation, Project administration, Writing – review & editing

* E-mail: libinana@126.com (BL); fanbaochao.0405@163.com (BF)

Affiliations Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Nanjing, China, Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base of Ministry of Science and Technology, Nanjing, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China, GuoTai (Taizhou) Center of Technology Innovation for Veterinary Biologicals, Taizhou, China, School of Life Sciences, Jiangsu University, Zhenjiang, China
⨯
Bin Li

Roles Conceptualization, Data curation, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: libinana@126.com (BL); fanbaochao.0405@163.com (BF)

Affiliations Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Nanjing, China, Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base of Ministry of Science and Technology, Nanjing, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China, GuoTai (Taizhou) Center of Technology Innovation for Veterinary Biologicals, Taizhou, China, School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China

https://orcid.org/0000-0003-1318-7081

⨯

MCL1 promotes porcine epidemic diarrhea virus replication by modulating arachidonic acid metabolic pathway

Hongqi Shang,
Shanshan Yang,
Min Sun,
Yongxiang Zhao,
Rongli Guo,
Wei Wang,
Bingxu Qian,
Yunchuan Li,
Mi Hu,
Xianyu Bian

Published: April 24, 2026
https://doi.org/10.1371/journal.ppat.1014170

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