Physiologic recovery of Mycobacterium tuberculosis from drug injury: A molecular study of post antibiotic effect in vitro and in vivo

Jo Hendrix; Reem Al Mubarak; Matthew J. Reichlen; Samuel T. Tabor; Adeline Bateman; Lisa M. Massoudi; Karen Rossmassler; Firat Kaya; Matthew D. Zimmerman; Holly Nielsen; Elizabeth A. Wynn; Martin I. Voskuil; Gregory T. Robertson; Camille M. Moore; Nicholas D. Walter

doi:10.1371/journal.ppat.1014131

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Open Access

Peer-reviewed

Research Article

Physiologic recovery of Mycobacterium tuberculosis from drug injury: A molecular study of post antibiotic effect in vitro and in vivo

Jo Hendrix,

Roles Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Division of Pulmonary, Allergy and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United states of America, Rocky Mountain Regional VA Medical Center, Aurora, Colorado, United states of America, Consortium for Applied Microbial Metrics, Aurora, Colorado, United states of America

https://orcid.org/0000-0001-9029-2390

⨯
Reem Al Mubarak,

Roles Data curation, Methodology, Writing – review & editing

Affiliations Division of Pulmonary, Allergy and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United states of America, Rocky Mountain Regional VA Medical Center, Aurora, Colorado, United states of America, Consortium for Applied Microbial Metrics, Aurora, Colorado, United states of America
⨯
Matthew J. Reichlen,

Roles Conceptualization, Methodology, Writing – review & editing

Affiliations Consortium for Applied Microbial Metrics, Aurora, Colorado, United states of America, Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United states of America
⨯
Samuel T. Tabor,

Roles Data curation, Methodology, Writing – review & editing

Affiliations Division of Pulmonary, Allergy and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United states of America, Rocky Mountain Regional VA Medical Center, Aurora, Colorado, United states of America, Consortium for Applied Microbial Metrics, Aurora, Colorado, United states of America, Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United states of America
⨯
Adeline Bateman,

Roles Methodology, Writing – review & editing

Affiliations Division of Pulmonary, Allergy and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United states of America, Rocky Mountain Regional VA Medical Center, Aurora, Colorado, United states of America, Consortium for Applied Microbial Metrics, Aurora, Colorado, United states of America
⨯
Lisa M. Massoudi,

Roles Data curation, Methodology, Writing – review & editing

Affiliation Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United states of America
⨯
Karen Rossmassler,

Roles Data curation, Writing – review & editing

Affiliations Rocky Mountain Regional VA Medical Center, Aurora, Colorado, United states of America, Consortium for Applied Microbial Metrics, Aurora, Colorado, United states of America, Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United states of America
⨯
Firat Kaya,

Roles Data curation, Writing – review & editing

Affiliation Center for Discovery and Innovation and Hackensack School of Medicine, Hackensack Meridian Health, Nutley, New Jersey, United states of America
⨯
Matthew D. Zimmerman,

Roles Methodology, Writing – review & editing

Affiliation Center for Discovery and Innovation and Hackensack School of Medicine, Hackensack Meridian Health, Nutley, New Jersey, United states of America
⨯
Holly Nielsen,

Roles Investigation, Methodology, Writing – review & editing

Affiliations Division of Pulmonary, Allergy and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United states of America, Rocky Mountain Regional VA Medical Center, Aurora, Colorado, United states of America, Consortium for Applied Microbial Metrics, Aurora, Colorado, United states of America
⨯
Elizabeth A. Wynn,

Roles Formal analysis, Writing – review & editing

Affiliations Rocky Mountain Regional VA Medical Center, Aurora, Colorado, United states of America, Consortium for Applied Microbial Metrics, Aurora, Colorado, United states of America, Center for Genes, Environment and Health, National Jewish Health, Denver, Colorado, United states of America
⨯
Martin I. Voskuil,

Roles Conceptualization, Project administration, Writing – review & editing

Affiliations Consortium for Applied Microbial Metrics, Aurora, Colorado, United states of America, Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United states of America
⨯
Gregory T. Robertson,

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

Affiliations Consortium for Applied Microbial Metrics, Aurora, Colorado, United states of America, Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United states of America
⨯
Camille M. Moore,

Roles Formal analysis, Writing – review & editing

Affiliations Consortium for Applied Microbial Metrics, Aurora, Colorado, United states of America, Center for Genes, Environment and Health, National Jewish Health, Denver, Colorado, United states of America, Department of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United states of America
⨯
Nicholas D. Walter

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: Nicholas.Walter@cuanschutz.edu

Affiliations Division of Pulmonary, Allergy and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United states of America, Rocky Mountain Regional VA Medical Center, Aurora, Colorado, United states of America, Consortium for Applied Microbial Metrics, Aurora, Colorado, United states of America

https://orcid.org/0000-0003-0126-1993

⨯

Physiologic recovery of Mycobacterium tuberculosis from drug injury: A molecular study of post antibiotic effect in vitro and in vivo

Jo Hendrix,
Reem Al Mubarak,
Matthew J. Reichlen,
Samuel T. Tabor,
Adeline Bateman,
Lisa M. Massoudi,
Karen Rossmassler,
Firat Kaya,
Matthew D. Zimmerman,
Holly Nielsen

Published: April 22, 2026
https://doi.org/10.1371/journal.ppat.1014131

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