Structural basis for substrate recognition and inhibition of thioredoxin glutathione reductase from Schistosoma japonicum: Implications for antiparasitic development

Songqing Wang; Wenbin Hong; Shukun Zhong; Zhijian Liang; Tianyichen Xiao; Chuchu Zhang; Xianshu Liu; Ziyi Dai; Yunlong Li; Siqi Wu; Qixu Cai; Caiming Wu; Yuxuan Huang; Peicheng Hong; Haixia Ren; Shaowei Li; Tianwei Lin; Xueqin Chen; Shuaiqin Huang

doi:10.1371/journal.ppat.1014125

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Open Access

Peer-reviewed

Research Article

Structural basis for substrate recognition and inhibition of thioredoxin glutathione reductase from Schistosoma japonicum: Implications for antiparasitic development

Songqing Wang,

Roles Conceptualization, Data curation, Investigation, Methodology, Software, Writing – original draft

Affiliation State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian, China
⨯
Wenbin Hong,

Roles Formal analysis, Investigation, Methodology, Validation, Visualization

Affiliation Xiamen Key Laboratory of Clinical Efficacy and Evidence Studies of Traditional Chinese Medicine, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China
⨯
Shukun Zhong,

Roles Data curation, Investigation, Methodology, Resources, Visualization

Affiliations Department of Medical Parasitology, Xiangya School of Basic Medical Sciences, Central South University, Changsha, Hunan, China, Key Laboratory of Hunan Province for Schistosomiasis Immunity and Transmission Control, Yueyang, Hunan, China
⨯
Zhijian Liang,

Roles Formal analysis, Methodology, Resources, Validation

Affiliation State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian, China
⨯
Tianyichen Xiao,

Roles Investigation, Resources, Software, Visualization

Affiliation State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian, China
⨯
Chuchu Zhang,

Roles Formal analysis, Methodology, Resources

Affiliation State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian, China
⨯
Xianshu Liu,

Roles Formal analysis, Resources, Visualization

Affiliations Department of Medical Parasitology, Xiangya School of Basic Medical Sciences, Central South University, Changsha, Hunan, China, Key Laboratory of Hunan Province for Schistosomiasis Immunity and Transmission Control, Yueyang, Hunan, China
⨯
Ziyi Dai,

Roles Formal analysis, Resources, Validation

Affiliations Department of Medical Parasitology, Xiangya School of Basic Medical Sciences, Central South University, Changsha, Hunan, China, Key Laboratory of Hunan Province for Schistosomiasis Immunity and Transmission Control, Yueyang, Hunan, China
⨯
Yunlong Li,

Roles Software, Visualization

Affiliation State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian, China
⨯
Siqi Wu,

Roles Formal analysis, Resources

Affiliation State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian, China
⨯
Qixu Cai,

Roles Software, Visualization

Affiliation State Key Laboratory of Vaccines for Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian, China
⨯
Caiming Wu,

Roles Formal analysis, Supervision

Affiliation State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian, China
⨯
Yuxuan Huang,

Roles Data curation, Formal analysis

Affiliation Xiamen Key Laboratory of Clinical Efficacy and Evidence Studies of Traditional Chinese Medicine, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China
⨯
Peicheng Hong,

Roles Formal analysis, Resources

Affiliation State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian, China
⨯
Haixia Ren,

Roles Resources

Affiliation State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian, China
⨯
Shaowei Li,

Roles Supervision

Affiliations National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Center of Biologic Products, National Innovation Platform for Industry-Education Integration in Vaccine Research, Xiamen University, Xiamen, Fujian, China, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, Fujian, China
⨯
Tianwei Lin ,

Roles Project administration, Resources, Supervision, Writing – review & editing

* E-mail: twlin@xmu.edu.cn (TL); xqchen@xmu.edu.cn (XC); sqhuang@csu.edu.cn (SH)

Affiliation State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian, China
⨯
Xueqin Chen ,

Roles Project administration, Resources, Supervision, Writing – review & editing

* E-mail: twlin@xmu.edu.cn (TL); xqchen@xmu.edu.cn (XC); sqhuang@csu.edu.cn (SH)

Affiliation Xiamen Key Laboratory of Clinical Efficacy and Evidence Studies of Traditional Chinese Medicine, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China
⨯
[ ... ],
Shuaiqin Huang

Roles Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: twlin@xmu.edu.cn (TL); xqchen@xmu.edu.cn (XC); sqhuang@csu.edu.cn (SH)

Affiliations Department of Medical Parasitology, Xiangya School of Basic Medical Sciences, Central South University, Changsha, Hunan, China, Key Laboratory of Hunan Province for Schistosomiasis Immunity and Transmission Control, Yueyang, Hunan, China

https://orcid.org/0000-0003-1846-7226

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Structural basis for substrate recognition and inhibition of thioredoxin glutathione reductase from Schistosoma japonicum: Implications for antiparasitic development

Songqing Wang,
Wenbin Hong,
Shukun Zhong,
Zhijian Liang,
Tianyichen Xiao,
Chuchu Zhang,
Xianshu Liu,
Ziyi Dai,
Yunlong Li,
Siqi Wu

Published: April 24, 2026
https://doi.org/10.1371/journal.ppat.1014125

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