Extensive diversity and impact of drug-resistant HIV-1 variants in individuals with prior virologic failure

• Melendhran Pillay ,

  Contributed equally to this work with: Melendhran Pillay, Manish C. Choudhary, Rinki Deo, Pravi Moodley, Nokukhanya Msomi, Jonathan Z. Li

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: melendhra.pillay@nhls.ac.za (MP); mchoudhary@bwh.harvard.edu (MCC); jli@bwh.harvard.edu (JZL)

  Affiliations Department of Virology, National Health Laboratory Service, Inkosi Albert Luthuli Central Hospital, Durban, South Africa, School of Laboratory Medicine and Medical Science, University of KwaZulu-Natal, Durban, South Africa

  https://orcid.org/0000-0002-5570-1010

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• Manish C. Choudhary ,

  Contributed equally to this work with: Melendhran Pillay, Manish C. Choudhary, Rinki Deo, Pravi Moodley, Nokukhanya Msomi, Jonathan Z. Li

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: melendhra.pillay@nhls.ac.za (MP); mchoudhary@bwh.harvard.edu (MCC); jli@bwh.harvard.edu (JZL)

  Affiliation Department of Medicine, Division of Infectious Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Rinki Deo ,

  Contributed equally to this work with: Melendhran Pillay, Manish C. Choudhary, Rinki Deo, Pravi Moodley, Nokukhanya Msomi, Jonathan Z. Li

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Medicine, Division of Infectious Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Serhiy Naumenko,

  Roles Data curation, Formal analysis, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Biostatistics, Harvard Chan School of Public Health, Boston, Massachusetts, United States of America, Newborn Screening Ontario, Ottawa, Ontario, Canada

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• Trevor J. Tamura,

  Roles Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Medicine, Division of Infectious Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Behzad Etemad,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Medicine, Division of Infectious Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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• Gregory Edelstein,

  Roles Writing – review & editing

  Affiliation Department of Medicine, Division of Infectious Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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• Aabida Khan,

  Roles Writing – review & editing

  Affiliations Department of Virology, National Health Laboratory Service, Inkosi Albert Luthuli Central Hospital, Durban, South Africa, School of Laboratory Medicine and Medical Science, University of KwaZulu-Natal, Durban, South Africa

  ⨯
• Kerusha Govender,

  Roles Writing – review & editing

  Affiliations Department of Virology, National Health Laboratory Service, Inkosi Albert Luthuli Central Hospital, Durban, South Africa, School of Laboratory Medicine and Medical Science, University of KwaZulu-Natal, Durban, South Africa

  ⨯
• Subitha Govender,

  Roles Writing – review & editing

  Affiliation Department of Virology, National Health Laboratory Service, Inkosi Albert Luthuli Central Hospital, Durban, South Africa

  ⨯
• Philip Tzou,

  Roles Writing – review & editing

  Affiliation Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, California, United States of America

  ⨯
• Mary Mick,

  Roles Writing – review & editing

  Affiliation Molecular Biology Core Facilities, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

  ⨯
• Zachary T. Herbert,

  Roles Writing – review & editing

  Affiliation Molecular Biology Core Facilities, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

  ⨯
• Winnie Muyindike,

  Roles Writing – review & editing

  Affiliation Mbarara University of Science and Technology, Mbarara, Uganda

  ⨯
• Mahomed-Yunus Suleman Moosa,

  Roles Writing – review & editing

  Affiliation Department of Infectious Disease, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa

  ⨯
• Jay Brijkumar,

  Roles Writing – review & editing

  Affiliation Department of Infectious Disease, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa

  ⨯
• Henry Sunpath,

  Roles Writing – review & editing

  Affiliation Department of Infectious Disease, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa

  ⨯
• Suzanne McCluskey,

  Roles Writing – review & editing

  Affiliation Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Benjamin Chimukangara,

  Roles Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Virology, National Health Laboratory Service, Inkosi Albert Luthuli Central Hospital, Durban, South Africa, School of Laboratory Medicine and Medical Science, University of KwaZulu-Natal, Durban, South Africa

  ⨯
• Sontaga C. Manyana,

  Roles Writing – review & editing

  Affiliation Department of Virology, National Health Laboratory Service, Inkosi Albert Luthuli Central Hospital, Durban, South Africa

  ⨯
• Lilishia Gounder,

  Roles Writing – review & editing

  Affiliations Department of Virology, National Health Laboratory Service, Inkosi Albert Luthuli Central Hospital, Durban, South Africa, School of Laboratory Medicine and Medical Science, University of KwaZulu-Natal, Durban, South Africa

  ⨯
• Raveen Parboosing,

  Roles Writing – review & editing

  Affiliation Division of Virology, National Health Laboratory Service & Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

  ⨯
• Kerri-Lee Francois,

  Roles Writing – review & editing

  Affiliations Department of Virology, National Health Laboratory Service, Inkosi Albert Luthuli Central Hospital, Durban, South Africa, School of Laboratory Medicine and Medical Science, University of KwaZulu-Natal, Durban, South Africa

  ⨯
• Robert Shafer,

  Roles Writing – review & editing

  Affiliation Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, California, United States of America

  ⨯
• Shannan Ho Sui,

  Roles Software, Visualization, Writing – review & editing

  Affiliation Department of Biostatistics, Harvard Chan School of Public Health, Boston, Massachusetts, United States of America

  ⨯
• Selvan Pillay,

  Roles Writing – review & editing

  Affiliations School of Laboratory Medicine and Medical Science, University of KwaZulu-Natal, Durban, South Africa, Adrenergy Research Innovations, KwaZulu-Natal, South Africa

  ⨯
• Vincent Marconi,

  Roles Funding acquisition, Writing – review & editing

  Affiliation Emory University School of Medicine and Rollins School of Public Health, Atlanta, GeorgiaUnited States of America

  ⨯
• Mark J. Siedner,

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Writing – original draft, Writing – review & editing

  Affiliations Mbarara University of Science and Technology, Mbarara, Uganda, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Africa Health Research Institute, KwaZulu-Natal, South Africa

  ⨯
• Pravi Moodley ,

  Contributed equally to this work with: Melendhran Pillay, Manish C. Choudhary, Rinki Deo, Pravi Moodley, Nokukhanya Msomi, Jonathan Z. Li

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Department of Virology, National Health Laboratory Service, Inkosi Albert Luthuli Central Hospital, Durban, South Africa, School of Laboratory Medicine and Medical Science, University of KwaZulu-Natal, Durban, South Africa

  ⨯
• Nokukhanya Msomi ,

  Contributed equally to this work with: Melendhran Pillay, Manish C. Choudhary, Rinki Deo, Pravi Moodley, Nokukhanya Msomi, Jonathan Z. Li

  Roles Conceptualization, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Department of Virology, National Health Laboratory Service, Inkosi Albert Luthuli Central Hospital, Durban, South Africa, School of Laboratory Medicine and Medical Science, University of KwaZulu-Natal, Durban, South Africa

  ⨯
•  [ ... ],
• Jonathan Z. Li

  Contributed equally to this work with: Melendhran Pillay, Manish C. Choudhary, Rinki Deo, Pravi Moodley, Nokukhanya Msomi, Jonathan Z. Li

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: melendhra.pillay@nhls.ac.za (MP); mchoudhary@bwh.harvard.edu (MCC); jli@bwh.harvard.edu (JZL)

  Affiliation Department of Medicine, Division of Infectious Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0001-9914-9662

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