Quantifying the role of pre-existing tissue resident cellular immunity in limiting respiratory virus transmission

Ananya Saha; Sarah E. Michalets; Ida Uddbäck; Hasan Ahmed; Jacob E. Kohlmeier; Rustom Antia; Katia Koelle

doi:10.1371/journal.ppat.1014082

Loading metrics

Open Access

Peer-reviewed

Research Article

Quantifying the role of pre-existing tissue resident cellular immunity in limiting respiratory virus transmission

Ananya Saha ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Visualization, Writing – original draft, Writing – review & editing

* E-mail: ananyasaha@uchicago.edu

Affiliation Department of Biology, Emory University, Atlanta, Georgia, United States of America

https://orcid.org/0009-0002-8205-0716

⨯
Sarah E. Michalets,

Roles Data curation, Formal analysis, Investigation, Project administration, Software, Writing – review & editing

Affiliation Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Ida Uddbäck,

Roles Data curation, Formal analysis, Investigation, Software, Writing – review & editing

Affiliation Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Hasan Ahmed,

Roles Methodology, Writing – review & editing

Affiliation Department of Biology, Emory University, Atlanta, Georgia, United States of America
⨯
Jacob E. Kohlmeier,

Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

Affiliations Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America, Emory Center of Excellence for Influenza Research and Response (CEIRR), Atlanta, Georgia, United States of America
⨯
Rustom Antia,

Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

Affiliations Department of Biology, Emory University, Atlanta, Georgia, United States of America, Emory Center of Excellence for Influenza Research and Response (CEIRR), Atlanta, Georgia, United States of America
⨯
Katia Koelle

Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – original draft, Writing – review & editing

Affiliations Department of Biology, Emory University, Atlanta, Georgia, United States of America, Emory Center of Excellence for Influenza Research and Response (CEIRR), Atlanta, Georgia, United States of America
⨯

Quantifying the role of pre-existing tissue resident cellular immunity in limiting respiratory virus transmission

Ananya Saha,
Sarah E. Michalets,
Ida Uddbäck,
Hasan Ahmed,
Jacob E. Kohlmeier,
Rustom Antia,
Katia Koelle

Published: April 21, 2026
https://doi.org/10.1371/journal.ppat.1014082

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Respiratory infections
Is the Subject Area "Respiratory infections" applicable to this article?

Thanks for your feedback.
Sendai virus
Is the Subject Area "Sendai virus" applicable to this article?

Thanks for your feedback.
Bioluminescence
Is the Subject Area "Bioluminescence" applicable to this article?

Thanks for your feedback.
Cell-mediated immunity
Is the Subject Area "Cell-mediated immunity" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Interferons
Is the Subject Area "Interferons" applicable to this article?

Thanks for your feedback.
Cytotoxic T cells
Is the Subject Area "Cytotoxic T cells" applicable to this article?

Thanks for your feedback.
Viral vaccines
Is the Subject Area "Viral vaccines" applicable to this article?

Thanks for your feedback.