Anatid herpesvirus 1 UL51 protein is palmitoylated by DHHC9 and DHHC18 for viral replication and virulence

Xiaolan Liu; Ruihao Zhang; Mingshu Wang; Anchun Cheng; Wei Zhang; Qiao Yang; Xumin Ou; Di Sun; Yu He; Bin Tian; Zhen Wu; Shaqiu Zhang; Juan Huang; Ying Wu; Yanling Yu; Ling Zhang; XinXin Zhao; Dekang Zhu; Shun Chen; Renyong Jia; Mafeng Liu

doi:10.1371/journal.ppat.1014076

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Open Access

Peer-reviewed

Research Article

Anatid herpesvirus 1 UL51 protein is palmitoylated by DHHC9 and DHHC18 for viral replication and virulence

Xiaolan Liu ,

Contributed equally to this work with: Xiaolan Liu, Ruihao Zhang, Anchun Cheng

Roles Data curation, Writing – original draft, Writing – review & editing

Affiliation Engineering Research Center of Southwest Animal Disease Prevention and Control Technology for Ministry of Education of the People’s Republic of China, International Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Agricultural Animal Diseases and Veterinary Public Health Key Laboratory of Sichuan Province, Research Center of Avian Disease and Institute of Veterinary Medicine and Immunology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China
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Ruihao Zhang ,

Contributed equally to this work with: Xiaolan Liu, Ruihao Zhang, Anchun Cheng

Roles Investigation, Methodology

Affiliation Engineering Research Center of Southwest Animal Disease Prevention and Control Technology for Ministry of Education of the People’s Republic of China, International Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Agricultural Animal Diseases and Veterinary Public Health Key Laboratory of Sichuan Province, Research Center of Avian Disease and Institute of Veterinary Medicine and Immunology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China
⨯
Mingshu Wang ,

Roles Data curation, Writing – review & editing

* E-mail: 2878665974@qq.com

Affiliation Engineering Research Center of Southwest Animal Disease Prevention and Control Technology for Ministry of Education of the People’s Republic of China, International Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Agricultural Animal Diseases and Veterinary Public Health Key Laboratory of Sichuan Province, Research Center of Avian Disease and Institute of Veterinary Medicine and Immunology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China

https://orcid.org/0000-0002-2893-0782

⨯
Anchun Cheng ,

Contributed equally to this work with: Xiaolan Liu, Ruihao Zhang, Anchun Cheng

Roles Funding acquisition, Project administration

Affiliation Engineering Research Center of Southwest Animal Disease Prevention and Control Technology for Ministry of Education of the People’s Republic of China, International Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Agricultural Animal Diseases and Veterinary Public Health Key Laboratory of Sichuan Province, Research Center of Avian Disease and Institute of Veterinary Medicine and Immunology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China

https://orcid.org/0000-0001-6093-353X

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Wei Zhang,

Roles Resources

Affiliation Sinopharm Yangzhou VAC Biological Engineering Co., Ltd., Yangzhou, China
⨯
Qiao Yang,

Roles Project administration, Software

Affiliation Engineering Research Center of Southwest Animal Disease Prevention and Control Technology for Ministry of Education of the People’s Republic of China, International Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Agricultural Animal Diseases and Veterinary Public Health Key Laboratory of Sichuan Province, Research Center of Avian Disease and Institute of Veterinary Medicine and Immunology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China
⨯
Xumin Ou,

Roles Data curation, Formal analysis

Affiliation Engineering Research Center of Southwest Animal Disease Prevention and Control Technology for Ministry of Education of the People’s Republic of China, International Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Agricultural Animal Diseases and Veterinary Public Health Key Laboratory of Sichuan Province, Research Center of Avian Disease and Institute of Veterinary Medicine and Immunology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China
⨯
Di Sun,

Roles Conceptualization, Data curation

Affiliation Engineering Research Center of Southwest Animal Disease Prevention and Control Technology for Ministry of Education of the People’s Republic of China, International Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Agricultural Animal Diseases and Veterinary Public Health Key Laboratory of Sichuan Province, Research Center of Avian Disease and Institute of Veterinary Medicine and Immunology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China
⨯
Yu He,

Roles Software, Supervision

Affiliation Engineering Research Center of Southwest Animal Disease Prevention and Control Technology for Ministry of Education of the People’s Republic of China, International Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Agricultural Animal Diseases and Veterinary Public Health Key Laboratory of Sichuan Province, Research Center of Avian Disease and Institute of Veterinary Medicine and Immunology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China
⨯
Bin Tian,

Roles Supervision, Validation

Affiliation Engineering Research Center of Southwest Animal Disease Prevention and Control Technology for Ministry of Education of the People’s Republic of China, International Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Agricultural Animal Diseases and Veterinary Public Health Key Laboratory of Sichuan Province, Research Center of Avian Disease and Institute of Veterinary Medicine and Immunology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China
⨯
Zhen Wu,

Roles Data curation, Visualization

Affiliation Engineering Research Center of Southwest Animal Disease Prevention and Control Technology for Ministry of Education of the People’s Republic of China, International Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Agricultural Animal Diseases and Veterinary Public Health Key Laboratory of Sichuan Province, Research Center of Avian Disease and Institute of Veterinary Medicine and Immunology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China
⨯
Shaqiu Zhang,

Roles Data curation, Validation

Affiliation Engineering Research Center of Southwest Animal Disease Prevention and Control Technology for Ministry of Education of the People’s Republic of China, International Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Agricultural Animal Diseases and Veterinary Public Health Key Laboratory of Sichuan Province, Research Center of Avian Disease and Institute of Veterinary Medicine and Immunology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China
⨯
Juan Huang,

Roles Supervision, Validation

Affiliation Engineering Research Center of Southwest Animal Disease Prevention and Control Technology for Ministry of Education of the People’s Republic of China, International Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Agricultural Animal Diseases and Veterinary Public Health Key Laboratory of Sichuan Province, Research Center of Avian Disease and Institute of Veterinary Medicine and Immunology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China
⨯
Ying Wu,

Roles Data curation, Supervision

Affiliation Engineering Research Center of Southwest Animal Disease Prevention and Control Technology for Ministry of Education of the People’s Republic of China, International Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Agricultural Animal Diseases and Veterinary Public Health Key Laboratory of Sichuan Province, Research Center of Avian Disease and Institute of Veterinary Medicine and Immunology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China
⨯
Yanling Yu,

Roles Data curation, Formal analysis

Affiliation Engineering Research Center of Southwest Animal Disease Prevention and Control Technology for Ministry of Education of the People’s Republic of China, International Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Agricultural Animal Diseases and Veterinary Public Health Key Laboratory of Sichuan Province, Research Center of Avian Disease and Institute of Veterinary Medicine and Immunology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China
⨯
Ling Zhang,

Roles Resources, Supervision

Affiliation Engineering Research Center of Southwest Animal Disease Prevention and Control Technology for Ministry of Education of the People’s Republic of China, International Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Agricultural Animal Diseases and Veterinary Public Health Key Laboratory of Sichuan Province, Research Center of Avian Disease and Institute of Veterinary Medicine and Immunology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China
⨯
XinXin Zhao,

Roles Data curation, Investigation

Affiliation Engineering Research Center of Southwest Animal Disease Prevention and Control Technology for Ministry of Education of the People’s Republic of China, International Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Agricultural Animal Diseases and Veterinary Public Health Key Laboratory of Sichuan Province, Research Center of Avian Disease and Institute of Veterinary Medicine and Immunology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China
⨯
Dekang Zhu,

Roles Resources, Supervision

Affiliation Engineering Research Center of Southwest Animal Disease Prevention and Control Technology for Ministry of Education of the People’s Republic of China, International Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Agricultural Animal Diseases and Veterinary Public Health Key Laboratory of Sichuan Province, Research Center of Avian Disease and Institute of Veterinary Medicine and Immunology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China
⨯
Shun Chen,

Roles Data curation, Methodology

Affiliation Engineering Research Center of Southwest Animal Disease Prevention and Control Technology for Ministry of Education of the People’s Republic of China, International Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Agricultural Animal Diseases and Veterinary Public Health Key Laboratory of Sichuan Province, Research Center of Avian Disease and Institute of Veterinary Medicine and Immunology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China
⨯
Renyong Jia,

Roles Investigation, Resources

Affiliation Engineering Research Center of Southwest Animal Disease Prevention and Control Technology for Ministry of Education of the People’s Republic of China, International Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Agricultural Animal Diseases and Veterinary Public Health Key Laboratory of Sichuan Province, Research Center of Avian Disease and Institute of Veterinary Medicine and Immunology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China
⨯
[ ... ],
Mafeng Liu

Roles Resources, Supervision

Affiliation Engineering Research Center of Southwest Animal Disease Prevention and Control Technology for Ministry of Education of the People’s Republic of China, International Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Agricultural Animal Diseases and Veterinary Public Health Key Laboratory of Sichuan Province, Research Center of Avian Disease and Institute of Veterinary Medicine and Immunology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China
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Anatid herpesvirus 1 UL51 protein is palmitoylated by DHHC9 and DHHC18 for viral replication and virulence

Xiaolan Liu,
Ruihao Zhang,
Mingshu Wang,
Anchun Cheng,
Wei Zhang,
Qiao Yang,
Xumin Ou,
Di Sun,
Yu He,
Bin Tian

Published: March 19, 2026
https://doi.org/10.1371/journal.ppat.1014076

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