Structural and evolutionary insights into DAF-12 interactions with transcriptional coactivators in parasitic nematodes

Manon Mallet; Yéléna Martin; João E. Carvalho; Eva Guchen; Remy Betous; Cherine Bechara; Anne Lespine; Michael Schubert; William Bourguet; Albane le Maire

doi:10.1371/journal.ppat.1014073

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Open Access

Peer-reviewed

Research Article

Structural and evolutionary insights into DAF-12 interactions with transcriptional coactivators in parasitic nematodes

Manon Mallet,

Roles Investigation, Visualization, Writing – review & editing

Affiliation Centre de Biologie Structurale (CBS), Université de Montpellier, CNRS, Inserm, Montpellier, France
⨯
Yéléna Martin ,

Contributed equally to this work with: Yéléna Martin, João E. Carvalho

Roles Investigation

Affiliation Centre de Biologie Structurale (CBS), Université de Montpellier, CNRS, Inserm, Montpellier, France
⨯
João E. Carvalho ,

Contributed equally to this work with: Yéléna Martin, João E. Carvalho

Roles Formal analysis, Investigation, Visualization

Affiliation Laboratoire de Biologie du Développement de Villefranche-sur-Mer, Institut de la Mer de Villefranche, Sorbonne Université, CNRS, Villefranche-sur-Mer, France
⨯
Eva Guchen,

Roles Investigation

Affiliation INTHERES, Université de Toulouse, INRAE, ENVT, Toulouse, France
⨯
Remy Betous,

Roles Investigation, Writing – review & editing

Affiliation INTHERES, Université de Toulouse, INRAE, ENVT, Toulouse, France
⨯
Cherine Bechara,

Roles Investigation

Affiliation IGF, Université de Montpellier, CNRS, INSERM, Montpellier, France
⨯
Anne Lespine,

Roles Funding acquisition

Affiliation INTHERES, Université de Toulouse, INRAE, ENVT, Toulouse, France
⨯
Michael Schubert,

Roles Writing – review & editing

Affiliation Laboratoire de Biologie du Développement de Villefranche-sur-Mer, Institut de la Mer de Villefranche, Sorbonne Université, CNRS, Villefranche-sur-Mer, France
⨯
William Bourguet,

Roles Conceptualization, Writing – review & editing

Affiliation Centre de Biologie Structurale (CBS), Université de Montpellier, CNRS, Inserm, Montpellier, France
⨯
Albane le Maire

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: albane.lemaire@cbs.cnrs.fr

Affiliation Centre de Biologie Structurale (CBS), Université de Montpellier, CNRS, Inserm, Montpellier, France

https://orcid.org/0000-0003-3336-2158

⨯

Structural and evolutionary insights into DAF-12 interactions with transcriptional coactivators in parasitic nematodes

Manon Mallet,
Yéléna Martin,
João E. Carvalho,
Eva Guchen,
Remy Betous,
Cherine Bechara,
Anne Lespine,
Michael Schubert,
William Bourguet,
Albane le Maire

Published: July 20, 2026
https://doi.org/10.1371/journal.ppat.1014073

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Nematode infections
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Parasitic diseases
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Crystal structure
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Brugia malayi
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Sequence alignment
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Larvae
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Luciferase
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