Neutralization of SARS-CoV-2 by IgM-14 via engagement of two distinct spike epitopes

• Yan Wang ,

  Roles Data curation, Investigation, Methodology, Writing – original draft, Writing – review & editing

  ¶☯ These authors contributed equally to this study

  Affiliation Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America

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• Yanping Hu ,

  Roles Data curation, Investigation, Methodology, Writing – original draft, Writing – review & editing

  ¶☯ These authors contributed equally to this study

  Affiliation Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America

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• Zhiqiang Ku,

  Roles Data curation, Investigation, Methodology, Writing – review & editing

  Affiliation Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

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• Jason Yeung,

  Roles Data curation, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, United States of America

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• Jing Zou,

  Roles Data curation, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America

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• Michael Woodson,

  Roles Data curation, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, United States of America

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• Nikolai S. Prokhorov,

  Roles Data curation, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, United States of America

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• Ekaterina S. Knyazhanskaya,

  Roles Data curation, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, United States of America

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• Haiqing Zhao,

  Roles Data curation, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, United States of America

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• Michael B. Sherman,

  Roles Data curation, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, United States of America

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• Zhiqiang An,

  Roles Resources, Writing – review & editing

  Affiliation Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

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• Stephen F. Carroll,

  Roles Resources, Writing – review & editing

  Affiliation IGM Biosciences Inc., 325 East Middlefield Road, Mountain View, California, United States of America

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• Pei-Yong Shi,

  Roles Funding acquisition, Writing – review & editing

  Affiliation Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, United States of America

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• Petr G. Leiman ,

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: pgleiman@utmb.edu (PGM); xuxie@utmb.edu (XX)

  Affiliation Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, United States of America

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• Xuping Xie

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: pgleiman@utmb.edu (PGM); xuxie@utmb.edu (XX)

  Affiliations Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America, Sealy Institute for Drug Discovery, University of Texas Medical Branch, Galveston, Texas, United States of America

  https://orcid.org/0000-0003-0918-016X

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